| pubmed-article:10463949 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10463949 | lifeskim:mentions | umls-concept:C0011065 | lld:lifeskim |
| pubmed-article:10463949 | lifeskim:mentions | umls-concept:C0254610 | lld:lifeskim |
| pubmed-article:10463949 | lifeskim:mentions | umls-concept:C0016030 | lld:lifeskim |
| pubmed-article:10463949 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:10463949 | lifeskim:mentions | umls-concept:C0258441 | lld:lifeskim |
| pubmed-article:10463949 | lifeskim:mentions | umls-concept:C0271510 | lld:lifeskim |
| pubmed-article:10463949 | lifeskim:mentions | umls-concept:C1366777 | lld:lifeskim |
| pubmed-article:10463949 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:10463949 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:10463949 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:10463949 | pubmed:dateCreated | 1999-9-17 | lld:pubmed |
| pubmed-article:10463949 | pubmed:abstractText | Interleukin-15 (IL-15) is a potent inhibitor of several apoptosis pathways. One prominent path toward apoptosis is the ligand-induced association of TNF receptor 1 (TNFR1) with death domain adaptor proteins. Studying if and how IL-15 blocks TNFR1-mediated apoptosis in a murine fibroblast cell line (L929), we show here that IL-15 blocks TNFR1-induced apoptosis via IL-15Ralpha chain signaling. The intracellular tail of IL-15Ralpha shows sequence homologies to the TRAF2 binding motifs of CD30 and CD40. Most important, binding of IL-15 to IL-15Ralpha successfully competes with the TNFR1 complex for TRAF2 binding, which may impede assembly of key adaptor proteins to the TNFR1 complex, and induces IkappaBalpha phosphorylation. Thus, IL-15Ralpha chain stimulation is a powerful deflector of cell death very early in the apoptosis signaling cascade, while TNF-alpha and IL-15 surface as major opponents in apoptosis control. | lld:pubmed |
| pubmed-article:10463949 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10463949 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10463949 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10463949 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10463949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10463949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10463949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10463949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10463949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10463949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10463949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10463949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10463949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10463949 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10463949 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10463949 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:10463949 | pubmed:issn | 0892-6638 | lld:pubmed |
| pubmed-article:10463949 | pubmed:author | pubmed-author:KrauseHH | lld:pubmed |
| pubmed-article:10463949 | pubmed:author | pubmed-author:PaulUU | lld:pubmed |
| pubmed-article:10463949 | pubmed:author | pubmed-author:RuckertRR | lld:pubmed |
| pubmed-article:10463949 | pubmed:author | pubmed-author:PohlTT | lld:pubmed |
| pubmed-article:10463949 | pubmed:author | pubmed-author:KunzendorfUU | lld:pubmed |
| pubmed-article:10463949 | pubmed:author | pubmed-author:BulanovaEE | lld:pubmed |
| pubmed-article:10463949 | pubmed:author | pubmed-author:Bulfone-PausS... | lld:pubmed |
| pubmed-article:10463949 | pubmed:author | pubmed-author:DurkopHH | lld:pubmed |
| pubmed-article:10463949 | pubmed:author | pubmed-author:BudagianVV | lld:pubmed |
| pubmed-article:10463949 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10463949 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:10463949 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10463949 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10463949 | pubmed:pagination | 1575-85 | lld:pubmed |
| pubmed-article:10463949 | pubmed:dateRevised | 2011-7-8 | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:meshHeading | pubmed-meshheading:10463949... | lld:pubmed |
| pubmed-article:10463949 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10463949 | pubmed:articleTitle | Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain. | lld:pubmed |
| pubmed-article:10463949 | pubmed:affiliation | Institute of Immunology, Department of Urology, Department of Pathology, University Hospital Benjamin Franklin, Free University, Berlin, Germany. bulfone@zedat.fu-berlin.de | lld:pubmed |
| pubmed-article:10463949 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10463949 | pubmed:publicationType | Retracted Publication | lld:pubmed |
| pubmed-article:10463949 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10463949 | lld:pubmed |
