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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1999-9-17
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pubmed:abstractText |
Interleukin-15 (IL-15) is a potent inhibitor of several apoptosis pathways. One prominent path toward apoptosis is the ligand-induced association of TNF receptor 1 (TNFR1) with death domain adaptor proteins. Studying if and how IL-15 blocks TNFR1-mediated apoptosis in a murine fibroblast cell line (L929), we show here that IL-15 blocks TNFR1-induced apoptosis via IL-15Ralpha chain signaling. The intracellular tail of IL-15Ralpha shows sequence homologies to the TRAF2 binding motifs of CD30 and CD40. Most important, binding of IL-15 to IL-15Ralpha successfully competes with the TNFR1 complex for TRAF2 binding, which may impede assembly of key adaptor proteins to the TNFR1 complex, and induces IkappaBalpha phosphorylation. Thus, IL-15Ralpha chain stimulation is a powerful deflector of cell death very early in the apoptosis signaling cascade, while TNF-alpha and IL-15 surface as major opponents in apoptosis control.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Il15ra protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-15,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-15,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TNF Receptor-Associated Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0892-6638
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1575-85
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pubmed:dateRevised |
2011-7-8
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pubmed:meshHeading |
pubmed-meshheading:10463949-Amino Acid Sequence,
pubmed-meshheading:10463949-Animals,
pubmed-meshheading:10463949-Apoptosis,
pubmed-meshheading:10463949-Binding Sites,
pubmed-meshheading:10463949-Fibroblasts,
pubmed-meshheading:10463949-Flow Cytometry,
pubmed-meshheading:10463949-Interleukin-15,
pubmed-meshheading:10463949-L Cells (Cell Line),
pubmed-meshheading:10463949-Macromolecular Substances,
pubmed-meshheading:10463949-Mice,
pubmed-meshheading:10463949-Proteins,
pubmed-meshheading:10463949-Receptors, Interleukin-15,
pubmed-meshheading:10463949-Receptors, Interleukin-2,
pubmed-meshheading:10463949-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:10463949-Recombinant Proteins,
pubmed-meshheading:10463949-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10463949-Sequence Alignment,
pubmed-meshheading:10463949-Sequence Homology, Amino Acid,
pubmed-meshheading:10463949-TNF Receptor-Associated Factor 2,
pubmed-meshheading:10463949-Transfection,
pubmed-meshheading:10463949-Tumor Necrosis Factor-alpha
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pubmed:year |
1999
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pubmed:articleTitle |
Death deflected: IL-15 inhibits TNF-alpha-mediated apoptosis in fibroblasts by TRAF2 recruitment to the IL-15Ralpha chain.
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pubmed:affiliation |
Institute of Immunology, Department of Urology, Department of Pathology, University Hospital Benjamin Franklin, Free University, Berlin, Germany. bulfone@zedat.fu-berlin.de
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pubmed:publicationType |
Journal Article,
Retracted Publication,
Research Support, Non-U.S. Gov't
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