Linked Life Data

10452037

Source:http://linkedlifedata.com/resource/pubmed/id/10452037

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1999-10-29
pubmed:abstractText
Investigating spatial and temporal expression and distribution of endogenous TGF alpha, and clarifying its role in burn wound healing. Immunohistochemical and mRNA dot blot hybridization approaches were adopted. Thermal injury can induce TGF alpha gene expression. The expression peaks at the time when repair cells migrate and proliferate most actively, and declines on near completion of epithelialization. Otherwise, the mRNA expression of EGF receptor manifests the same change as TGF alpha's. Immunohistochemical investigation indicates that TGF alpha is mainly distributed in the survived hair follicles and reepithelialized cell layers, and the immunoreactive staining is proportional to epidermal cell growth and migration. Thermal injury can induce endogenous TGF alpha and EGF receptor expression, which is well controlled and correlated with the migration and proliferation of keratinocytes. Endogenous TGF alpha plays a positive role in regulation of wound healing.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1000-7806
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
323-5
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1997
pubmed:articleTitle
[Experimental study of temporal expression of endogenous TGF alpha in partial thickness scalded wounds].
pubmed:affiliation
Department of Burn Surgery, Changhai Hospital, Second Military Medical University, Shanghai.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't