Source:http://linkedlifedata.com/resource/pubmed/id/10447260
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1999-9-21
|
pubmed:abstractText |
Recent genome screening studies have identified novel regions of possible interest for susceptibility to type 1 diabetes. One of these is a 30-35 cM region mapping to 16q22-q24 (D16S515-D16S520), where also the gene encoding NAD(P)H: quinone oxidoreductase (NQO1) maps. Data has suggested association of a polymorphism (P187S) in the NQO1 gene and type 1 diabetes. NQO1 is involved in protection against oxidative stress, which is likely to be involved in beta-cell destruction. By use of the transmission disequilibrium test (TDT), we analyzed the P187S polymorphism for association to type 1 diabetes in a population-based sample of 247 Danish nuclear type 1 diabetic families. Random transmission patterns were observed to all affected offspring (p(tdt) = 0.82), to index cases (P(tdt) = 0.77), as well as to unaffected offspring (P(tdt) = 0.93). Hence, the NQO1 polymorphism is not likely to be an etiological mutation underlying the reported linkage of the 16q22-q24 region.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:issn |
1059-7794
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
14
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
67-70
|
pubmed:dateRevised |
2010-11-18
|
pubmed:meshHeading |
pubmed-meshheading:10447260-Chromosomes, Human, Pair 16,
pubmed-meshheading:10447260-Denmark,
pubmed-meshheading:10447260-Diabetes Mellitus, Type 1,
pubmed-meshheading:10447260-Female,
pubmed-meshheading:10447260-Genetic Linkage,
pubmed-meshheading:10447260-Genetic Predisposition to Disease,
pubmed-meshheading:10447260-Heterozygote,
pubmed-meshheading:10447260-Humans,
pubmed-meshheading:10447260-Linkage Disequilibrium,
pubmed-meshheading:10447260-Male,
pubmed-meshheading:10447260-NAD(P)H Dehydrogenase (Quinone),
pubmed-meshheading:10447260-Polymorphism, Genetic
|
pubmed:year |
1999
|
pubmed:articleTitle |
No linkage of P187S polymorphism in NAD(P)H: quinone oxidoreductase (NQO1/DIA4) and type 1 diabetes in the Danish population. DIEGG and DSGD. Danish IDDM Epidemiology and Genetics Group and The Danish Study Group of Diabetes in Childhood.
|
pubmed:affiliation |
Steno Diabetes Center, Gentofte, Denmark.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|