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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
1999-9-7
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pubmed:abstractText |
Interleukin (IL) 17 is a proinflammatory cytokine secreted mainly by activated human memory CD4 T cells that induces IL-6, IL-8, and nitric oxide. Because IL-6 and IL-8 have been implicated in the pathogenesis of cervical cancer, we investigated the action of IL-17 on human cervical tumor cell lines in vitro and in vivo. We showed that in vitro, IL-17 increases IL-6 and IL-8 secretion by cervical carcinoma cell lines at both protein and mRNA levels. No direct effect of IL-17 on in vitro proliferation of cervical tumor cell lines could be demonstrated. However, two cervical cell lines transfected with a cDNA encoding IL-17 exhibited a significant increase in tumor size as compared to the parent tumor when transplanted in nude mice. This enhanced tumor growth elicited by IL-17 was associated with increased expression of IL-6 and macrophage recruitment at the tumor site. A potential role of IL-17 in modulation of the human cervical tumor phenotype was also supported by its expression on the cervical tumor in patients with CD4 infiltration. IL-17 therefore behaves like a T-cell-specific cytokine with paradoxical tumor-promoting activity. This may partially explain previous reports concerning the deleterious effect of CD4 T cells in cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0008-5472
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pubmed:author |
pubmed-author:BanchereauJJ,
pubmed-author:ClaretEE,
pubmed-author:CouturierJJ,
pubmed-author:FossiezFF,
pubmed-author:FridmanW HWH,
pubmed-author:GalinhaAA,
pubmed-author:GenJJ,
pubmed-author:JoyeuxII,
pubmed-author:LebecqueSS,
pubmed-author:MosseriVV,
pubmed-author:Sastre-GarauXX,
pubmed-author:Sautès-FridmanCC,
pubmed-author:TartourEE,
pubmed-author:VirágBB,
pubmed-author:WijdenesJJ
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3698-704
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10446984-Animals,
pubmed-meshheading:10446984-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10446984-Carcinogens,
pubmed-meshheading:10446984-Female,
pubmed-meshheading:10446984-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10446984-HeLa Cells,
pubmed-meshheading:10446984-Humans,
pubmed-meshheading:10446984-Interleukin-17,
pubmed-meshheading:10446984-Interleukin-6,
pubmed-meshheading:10446984-Interleukin-8,
pubmed-meshheading:10446984-Male,
pubmed-meshheading:10446984-Melanoma,
pubmed-meshheading:10446984-Mice,
pubmed-meshheading:10446984-Mice, Nude,
pubmed-meshheading:10446984-Neoplasm Proteins,
pubmed-meshheading:10446984-Neoplasm Transplantation,
pubmed-meshheading:10446984-Recombinant Fusion Proteins,
pubmed-meshheading:10446984-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:10446984-T-Lymphocytes,
pubmed-meshheading:10446984-Transfection,
pubmed-meshheading:10446984-Tumor Cells, Cultured,
pubmed-meshheading:10446984-Uterine Cervical Neoplasms
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pubmed:year |
1999
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pubmed:articleTitle |
Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice.
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pubmed:affiliation |
Unité d'Immunologie Clinique, INSERM U 225 and Université Pierre et Marie Curie, Paris, France. etartour@curie.fr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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