Source:http://linkedlifedata.com/resource/pubmed/id/10446076
Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
8
|
pubmed:dateCreated |
1999-8-24
|
pubmed:abstractText |
Uniparental disomy (UPD), a rare inheritance of 2 copies of a single chromosome homolog or a region of a chromosome from one parent, can result in various autosomal recessive diseases. Abetalipoproteinemia (ABL) is a rare autosomal recessive deficiency of apoB-containing lipoproteins caused by a microsomal triglyceride transfer protein (MTP) deficiency. In this study, we describe a patient with ABL inherited as a homozygous intron 9 splice acceptor G(-1)-to-A mutation of the transfer protein gene. This mutation alters the splicing of the mRNA, resulting in a 36 amino acids, in-frame deletion of sequence encoded by exon 10. We analyzed chromosome 4, including MTP gene (4q22-24), using short tandem repeat markers. The proband has only his mother's genes in chromosome 4q spanning a 150-centimorgan region; ie, segmental maternal isodisomy 4q21-35, probably due to mitotic recombination. Nonpaternity between the proband and his father was excluded using 6 polymorphic markers from different chromosomes (paternity probability, 0.999). Maternal isodisomy (maternal UPD 4q) was the basis for homozygosity of the MTP gene mutation in this patient.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
|
pubmed:issn |
1079-5642
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
19
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1950-5
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:10446076-Abetalipoproteinemia,
pubmed-meshheading:10446076-Adult,
pubmed-meshheading:10446076-Carrier Proteins,
pubmed-meshheading:10446076-Chromosomes, Human, Pair 4,
pubmed-meshheading:10446076-Family Health,
pubmed-meshheading:10446076-History, 16th Century,
pubmed-meshheading:10446076-Humans,
pubmed-meshheading:10446076-Isochromosomes,
pubmed-meshheading:10446076-Lipids,
pubmed-meshheading:10446076-Male,
pubmed-meshheading:10446076-Microsomes,
pubmed-meshheading:10446076-Mothers,
pubmed-meshheading:10446076-Pedigree,
pubmed-meshheading:10446076-Point Mutation,
pubmed-meshheading:10446076-RNA Splicing,
pubmed-meshheading:10446076-Tandem Repeat Sequences
|
pubmed:year |
1999
|
pubmed:articleTitle |
Abetalipoproteinemia caused by maternal isodisomy of chromosome 4q containing an intron 9 splice acceptor mutation in the microsomal triglyceride transfer protein gene.
|
pubmed:affiliation |
Second Department of Internal Medicine, Department of General Medicine School of Medicine, Kanazawa University, Takara-machi 13-1 Kanazawa, Ishikawa 920-8641, Japan.
|
pubmed:publicationType |
Journal Article,
Historical Article,
Research Support, Non-U.S. Gov't
|