Source:http://linkedlifedata.com/resource/pubmed/id/10432437
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
1999-9-23
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| pubmed:abstractText |
An important characteristic of autoimmune diseases is their association with major histocompatibility complex class I and class II alleles. In this study, we compared insulin-dependent diabetes mellitus (IDDM) with idiopathic dilated cardiomyopathy (IDC) from a strictly immunologic perspective. Although the target organs are different, being in one case the insulin-producing beta cells of the pancreas and in the other case the myocytes of the heart, many aspects of the tissue-specific immune destruction are common. Similar yet different Coxsackievirus B strains with either pancreotropic or cardiotropic specificity are able to perpetrate the first injury of the respective target tissue. Their shared capacity of inducing a superantigenic reaction further enhances the damage. Once previously secluded autoantigens are then exposed to the immune system, the tissue injury is completed via a more conventional type of immune response. On the basis of the compounded results we obtained, it is possible to propose that the same HLA-DQ molecules which are able to protect the individuals from IDDM (e.g., HLA-DQA1*0102, DQB1*0602) seem to favour the enteroviral attack to the myocardium, while alleles which confer the strongest susceptibility to IDDM (e.g., DQA1*0301, DQB1*0302), seem unable to sustain the immune attack against the heart.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0393-974X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
14-26
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10432437-Adolescent,
pubmed-meshheading:10432437-Adult,
pubmed-meshheading:10432437-Animals,
pubmed-meshheading:10432437-Autoimmune Diseases,
pubmed-meshheading:10432437-Cardiomyopathy, Dilated,
pubmed-meshheading:10432437-Cercopithecus aethiops,
pubmed-meshheading:10432437-Child,
pubmed-meshheading:10432437-Child, Preschool,
pubmed-meshheading:10432437-Coxsackievirus Infections,
pubmed-meshheading:10432437-Diabetes Mellitus, Type 1,
pubmed-meshheading:10432437-Disease Susceptibility,
pubmed-meshheading:10432437-Enterovirus B, Human,
pubmed-meshheading:10432437-Female,
pubmed-meshheading:10432437-Genes, T-Cell Receptor alpha,
pubmed-meshheading:10432437-Genes, T-Cell Receptor beta,
pubmed-meshheading:10432437-HLA-DQ Antigens,
pubmed-meshheading:10432437-HeLa Cells,
pubmed-meshheading:10432437-Heart,
pubmed-meshheading:10432437-Humans,
pubmed-meshheading:10432437-Immunohistochemistry,
pubmed-meshheading:10432437-Infant,
pubmed-meshheading:10432437-Male,
pubmed-meshheading:10432437-Monocytes,
pubmed-meshheading:10432437-Pancreas,
pubmed-meshheading:10432437-Superantigens,
pubmed-meshheading:10432437-Vero Cells
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| pubmed:articleTitle |
The same HLA-DQ alleles determine either susceptibility or resistance to different coxsackievirus-mediated autoimmune diseases.
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| pubmed:affiliation |
Department of Pediatrics, University of Pittsburgh School of Medicine, Rangos Research Center, Children's Hospital of Pittsburgh, Pennsylvania, USA.
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| pubmed:publicationType |
Journal Article,
Comparative Study
|