Source:http://linkedlifedata.com/resource/pubmed/id/10426197
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1999-9-27
|
| pubmed:abstractText |
The cellular changes leading to carcinoma of the lip are still not completely understood. This study was carried out on 44 malignant and potentially malignant lesions of the lower lip [30 squamous cell carcinomas (SCC), 7 actinic cheilitis, 3 leukoplakias, and 4 nodal metastases from lower lip SCC]. Silver-stained nucleolar organizer regions (AgNORs) and the immunohistochemical expression of proliferating cell nuclear antigen (PCNA), p53, and c-myc were evaluated on formalin-fixed, paraffin-embedded sections. The results indicate that the size and numbers of AgNORs and the percentage of PCNA-positive cells are sensitive parameters for discriminating between potentially malignant lesions and SCC, and for the prognostic sub-typing of lower lip SCC. Furthermore, while p53 positivity was found more frequently in high-grade carcinomas, p53-positive cellular clones were also found in some potentially malignant lesions, a finding probably related to ultraviolet-related cellular damage. These p53-positive lesions could be considered at higher risk of progression to malignancy than the p53-negative ones, although there is no evidence for this as yet. c-myc positivity was found only in some high-grade carcinomas and metastases, and appeared correlated with the later phases of lip carcinogenesis. The combined evaluation of the proliferation status, together with the changes in p53 and c-myc oncoproteins, might constitute useful markers for the prognostic evaluation of potentially malignant, as well as malignant, lesions of the lip.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
D
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0904-2512
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
28
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
252-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10426197-Adolescent,
pubmed-meshheading:10426197-Adult,
pubmed-meshheading:10426197-Aged,
pubmed-meshheading:10426197-Aged, 80 and over,
pubmed-meshheading:10426197-Carcinoma, Squamous Cell,
pubmed-meshheading:10426197-Diagnosis, Differential,
pubmed-meshheading:10426197-Female,
pubmed-meshheading:10426197-Humans,
pubmed-meshheading:10426197-Immunohistochemistry,
pubmed-meshheading:10426197-Lip Neoplasms,
pubmed-meshheading:10426197-Male,
pubmed-meshheading:10426197-Middle Aged,
pubmed-meshheading:10426197-Nucleolus Organizer Region,
pubmed-meshheading:10426197-Precancerous Conditions,
pubmed-meshheading:10426197-Prognosis,
pubmed-meshheading:10426197-Proliferating Cell Nuclear Antigen,
pubmed-meshheading:10426197-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:10426197-Silver Staining,
pubmed-meshheading:10426197-Tumor Suppressor Protein p53
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Potentially malignant and malignant lesions of the lip. Role of silver staining nucleolar organizer regions, proliferating cell nuclear antigen, p53, and c-myc in differentiation and prognosis.
|
| pubmed:affiliation |
Department of Biomorphological and Functional Sciences, University Federico II, Naples, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|