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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6741
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pubmed:dateCreated |
1999-8-5
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pubmed:abstractText |
Wingless (Wg) is a member of the Wnt family of growth factors, secreted proteins that control proliferation and differentiation during development. Studies in Drosophila have shown that responses to Wg require cell-surface heparan sulphate, a glycosaminoglycan component of proteoglycans. These findings suggest that a cell-surface proteoglycan is a component of a Wg/Wnt receptor complex. We demonstrate here that the protein encoded by the division abnormally delayed (dally) gene is a cell-surface, heparan-sulphate-modified proteoglycan. dally partial loss-of-function mutations compromise Wg-directed events, and disruption of dally function with RNA interference produces phenotypes comparable to those found with RNA interference of wg or frizzled (fz)/Dfz2. Ectopic expression of Dally potentiates Wg signalling without altering levels of Wg and can rescue a wg partial loss-of-function mutant. We also show that dally, a regulator of Decapentaplegic (Dpp) signalling during post-embryonic development, has tissue-specific effects on Wg and Dpp signalling. Dally can therefore differentially influence signalling mediated by two growth factors, and may form a regulatory component of both Wg and Dpp receptor complexes.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glycosylphosphatidylinositols,
http://linkedlifedata.com/resource/pubmed/chemical/Heparan Sulfate Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insect Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteoglycans,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt1 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/dally protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/dpp protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/engrail protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/wg protein, Drosophila
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0028-0836
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pubmed:author |
pubmed-author:ArcherMM,
pubmed-author:FoxBB,
pubmed-author:FutchTT,
pubmed-author:HumphreyMM,
pubmed-author:KaluzaVV,
pubmed-author:KamimuraKK,
pubmed-author:NakatoHH,
pubmed-author:OlsonSS,
pubmed-author:ROSED JDJ,
pubmed-author:SelleckS BSB,
pubmed-author:SiegfriedEE,
pubmed-author:StaatsPP,
pubmed-author:TsudaMM
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
400
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
276-80
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10421371-Animals,
pubmed-meshheading:10421371-Animals, Genetically Modified,
pubmed-meshheading:10421371-Cloning, Molecular,
pubmed-meshheading:10421371-Drosophila,
pubmed-meshheading:10421371-Drosophila Proteins,
pubmed-meshheading:10421371-Epidermis,
pubmed-meshheading:10421371-Female,
pubmed-meshheading:10421371-Genes, Insect,
pubmed-meshheading:10421371-Genetic Techniques,
pubmed-meshheading:10421371-Genitalia,
pubmed-meshheading:10421371-Glycosylphosphatidylinositols,
pubmed-meshheading:10421371-Heparan Sulfate Proteoglycans,
pubmed-meshheading:10421371-Homeodomain Proteins,
pubmed-meshheading:10421371-Insect Proteins,
pubmed-meshheading:10421371-Larva,
pubmed-meshheading:10421371-Male,
pubmed-meshheading:10421371-Membrane Glycoproteins,
pubmed-meshheading:10421371-Mutation,
pubmed-meshheading:10421371-Proteoglycans,
pubmed-meshheading:10421371-Proto-Oncogene Proteins,
pubmed-meshheading:10421371-RNA,
pubmed-meshheading:10421371-Signal Transduction,
pubmed-meshheading:10421371-Transcription Factors,
pubmed-meshheading:10421371-Wnt1 Protein
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pubmed:year |
1999
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pubmed:articleTitle |
The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila.
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pubmed:affiliation |
Department of Biology, Tokyo Metropolitan University, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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