| pubmed-article:10417151 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10417151 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10417151 | lifeskim:mentions | umls-concept:C0521346 | lld:lifeskim |
| pubmed-article:10417151 | lifeskim:mentions | umls-concept:C0033809 | lld:lifeskim |
| pubmed-article:10417151 | lifeskim:mentions | umls-concept:C0014597 | lld:lifeskim |
| pubmed-article:10417151 | lifeskim:mentions | umls-concept:C0079633 | lld:lifeskim |
| pubmed-article:10417151 | lifeskim:mentions | umls-concept:C0521447 | lld:lifeskim |
| pubmed-article:10417151 | lifeskim:mentions | umls-concept:C0028135 | lld:lifeskim |
| pubmed-article:10417151 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:10417151 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10417151 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:10417151 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:10417151 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:10417151 | pubmed:dateCreated | 1999-8-12 | lld:pubmed |
| pubmed-article:10417151 | pubmed:abstractText | Persistent infection with Pseudomonas aeruginosa increases interleukin-8 (IL-8) levels and causes dense neutrophil infiltrations in the airways of patients with chronic airway diseases. Recently, we have reported that nitrite reductase from P. aeruginosa induces the production of IL-8 in respiratory cells, including bronchial epithelial cells. To determine the molecular mechanism(s) of nitrite reductase-induced IL-8 expression in respiratory cells, A549 epithelial cells were transfected with plasmids containing serial deletions of the 5'-flanking region of the IL-8 gene and then exposed to nitrite reductase. Nitrite reductase significantly enhanced IL-8 gene promoter-driven reporter activity. This increased IL-8 gene expression was inhibited by mutating the nuclear factor-kappaB (NF-kappaB) binding element. Nitrite reductase enhanced nuclear localization of the NF-kappaB binding complex. Furthermore, nitrite reductase induced the degradation of IkappaBalpha, the major cytoplasmic inhibitor of NF-kappaB, and the expression of IkappaBalpha mRNA. These data support the critical role of the activation of NF-kappaB in nitrite reductase-induced IL-8 gene expression in airway epithelium. | lld:pubmed |
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| pubmed-article:10417151 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10417151 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10417151 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10417151 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10417151 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10417151 | pubmed:issn | 0019-9567 | lld:pubmed |
| pubmed-article:10417151 | pubmed:author | pubmed-author:OishiKK | lld:pubmed |
| pubmed-article:10417151 | pubmed:author | pubmed-author:MoriNN | lld:pubmed |
| pubmed-article:10417151 | pubmed:author | pubmed-author:NagatakeTT | lld:pubmed |
| pubmed-article:10417151 | pubmed:author | pubmed-author:YamamotoNN | lld:pubmed |
| pubmed-article:10417151 | pubmed:author | pubmed-author:MatsushimaKK | lld:pubmed |
| pubmed-article:10417151 | pubmed:author | pubmed-author:Ry?RR | lld:pubmed |
| pubmed-article:10417151 | pubmed:author | pubmed-author:MukaidaNN | lld:pubmed |
| pubmed-article:10417151 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10417151 | pubmed:volume | 67 | lld:pubmed |
| pubmed-article:10417151 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10417151 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10417151 | pubmed:pagination | 3872-8 | lld:pubmed |
| pubmed-article:10417151 | pubmed:dateRevised | 2011-8-31 | lld:pubmed |
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| pubmed-article:10417151 | pubmed:meshHeading | pubmed-meshheading:10417151... | lld:pubmed |
| pubmed-article:10417151 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10417151 | pubmed:articleTitle | Essential role of transcription factor nuclear factor-kappaB in regulation of interleukin-8 gene expression by nitrite reductase from Pseudomonas aeruginosa in respiratory epithelial cells. | lld:pubmed |
| pubmed-article:10417151 | pubmed:affiliation | Department of Preventive Medicine and AIDS Research, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan. n-mori@net.nagasaki-u.ac.jp | lld:pubmed |
| pubmed-article:10417151 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10417151 | pubmed:publicationType | Retracted Publication | lld:pubmed |
| pubmed-article:10417151 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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