Source:http://linkedlifedata.com/resource/pubmed/id/10404054
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
1999-8-19
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| pubmed:abstractText |
Since the CTLA-4 molecule expressed on activated T lymphocytes has recently been suggested to be an important negative regulator in autoimmune diseases, this study was undertaken to investigate the expression and function of CTLA-4 on synovial T cells from patients with rheumatoid arthritis. CTLA-4-expressing T cells were detected using a dual fluorescence flow cytometric method. Only a small percentage of peripheral blood T cells from patients with rheumatoid arthritis had detectable surface CTLA-4 expression (mean +/- SD, 1. 89 +/- 1.92%). However, the levels of CTLA-4-positive T cells was increased significantly in rheumatoid synovial fluids (5.44 +/- 4. 96%) and synovial membranes (28.76 +/- 14.30%). To explore the role of CTLA-4 molecule in the inflammation of rheumatoid joints, CTLA-4 was blocked with anti-CTLA-4 antibody to assess its effects on the production of tumour necrosis factor alpha and interleukin 1beta in synovial fluid mononuclear cell culture. The addition of anti-CTLA-4 antibody enhanced the production of tumour necrosis factor alpha and interleukin 1beta in a dose-dependent manner. The data suggest that the expression of CTLA-4 plays a down-regulatory role in rheumatoid articular inflammation. We thus concluded that CTLA-4 was up-regulated on synovial T cells from patients with RA, and the increased CTLA-4 expression might exert a down-regulation effect on tumour necrosis factor alpha and interleukin 1beta production.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA-4 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/CTLA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
|
| pubmed:status |
MEDLINE
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| pubmed:month |
Jul
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| pubmed:issn |
0300-9475
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
50
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
68-72
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:10404054-Adult,
pubmed-meshheading:10404054-Aged,
pubmed-meshheading:10404054-Antigens, CD,
pubmed-meshheading:10404054-Antigens, Differentiation,
pubmed-meshheading:10404054-Arthritis, Rheumatoid,
pubmed-meshheading:10404054-CTLA-4 Antigen,
pubmed-meshheading:10404054-Case-Control Studies,
pubmed-meshheading:10404054-Cells, Cultured,
pubmed-meshheading:10404054-Down-Regulation,
pubmed-meshheading:10404054-Female,
pubmed-meshheading:10404054-Humans,
pubmed-meshheading:10404054-Immunoconjugates,
pubmed-meshheading:10404054-Interleukin-1,
pubmed-meshheading:10404054-Male,
pubmed-meshheading:10404054-Middle Aged,
pubmed-meshheading:10404054-Synovial Fluid,
pubmed-meshheading:10404054-Synovial Membrane,
pubmed-meshheading:10404054-T-Lymphocytes,
pubmed-meshheading:10404054-Tumor Necrosis Factor-alpha
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| pubmed:year |
1999
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| pubmed:articleTitle |
Increased expression of down-regulatory CTLA-4 molecule on T lymphocytes from rheumatoid synovial compartment.
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| pubmed:affiliation |
Department of Internal Medicine, Medical College, National Cheng Kung University Hospital, Tainan, Taiwan, Republic of China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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