Source:http://linkedlifedata.com/resource/pubmed/id/10395849
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1999-9-7
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pubmed:abstractText |
A total of 151 previously untreated patients infected with human immunodeficiency virus type 1 (HIV-1) with CD4 cell counts >/=200/microL and plasma HIV-1 RNA levels of 10,000-100,000 copies/mL were randomly assigned to 24 weeks of open-labeled stavudine plus didanosine (group 1), zidovudine plus lamivudine (group 2), or stavudine plus didanosine followed by zidovudine plus lamivudine (group 3). The mean decrease in HIV-1 RNA level was greater in group 1 (2.26 log10 copies/mL) than in groups 2 (1.26 log10 copies/mL) or 3 (1.58 log10 copies/mL; P<.0001). The mean increase in CD4 cell counts was greater in groups 1 (124 cells/microL) and 3 (118 cells/microL) than in group 2 (62 cells/microL; P=.02). All regimens were generally well tolerated. The combination of stavudine plus didanosine reduced plasma HIV-1 RNA concentrations and increased CD4 cell counts more effectively than did the combination of zidovudine plus lamivudine or the regimen alternating both combinations.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-HIV Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Didanosine,
http://linkedlifedata.com/resource/pubmed/chemical/Lamivudine,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Reverse Transcriptase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Stavudine,
http://linkedlifedata.com/resource/pubmed/chemical/Zidovudine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-1899
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
180
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
351-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10395849-Adult,
pubmed-meshheading:10395849-Anti-HIV Agents,
pubmed-meshheading:10395849-CD4 Lymphocyte Count,
pubmed-meshheading:10395849-Didanosine,
pubmed-meshheading:10395849-Drug Administration Schedule,
pubmed-meshheading:10395849-Drug Therapy, Combination,
pubmed-meshheading:10395849-Female,
pubmed-meshheading:10395849-HIV Infections,
pubmed-meshheading:10395849-HIV-1,
pubmed-meshheading:10395849-Humans,
pubmed-meshheading:10395849-Lamivudine,
pubmed-meshheading:10395849-Male,
pubmed-meshheading:10395849-RNA, Viral,
pubmed-meshheading:10395849-Reverse Transcriptase Inhibitors,
pubmed-meshheading:10395849-Stavudine,
pubmed-meshheading:10395849-Treatment Outcome,
pubmed-meshheading:10395849-Viremia,
pubmed-meshheading:10395849-Zidovudine
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pubmed:year |
1999
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pubmed:articleTitle |
The ALBI trial: a randomized controlled trial comparing stavudine plus didanosine with zidovudine plus lamivudine and a regimen alternating both combinations in previously untreated patients infected with human immunodeficiency virus.
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pubmed:affiliation |
Clinique des Maladies Infectieuses, Hôpital Saint-Louis, 75475 Paris Cedex 10, France. molina@chu-stlouis.fr
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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