Source:http://linkedlifedata.com/resource/umls/id/C0164662
MSH: A dideoxynucleoside analog that inhibits reverse transcriptase and has in vitro activity against HIV.,CSP: nucleoside analog; used as an antiviral agent.,NCI: A drug that belongs to the family of drugs called nucleoside analogues. It is used to treat infection caused by viruses.,PDQ: A synthetic nucleoside, analog of didehydro-3-deoxythymidine with potent antiretroviral activity. In vivo, stavudine is phosphorylated by cellular kinases to the active metabolite stavudine triphosphate; this metabolite inhibits the activity of HIV reverse transcriptase both by competing with the natural substrate deoxythymidine triphosphate and by incorporation into viral DNA causing a termination of DNA chain elongation (due to the lack the essential 3'-OH group). Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41064&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41064&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:8