Source:http://linkedlifedata.com/resource/pubmed/id/10395843
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-9-7
|
| pubmed:abstractText |
Polymorphic products of genes in the HLA region contributing to variability in the course of human immunodeficiency virus type 1 (HIV-1) infection were identified by screening 375 Caucasian seroconverters who were aggregated from 3 cohorts. AIDS-free time was related to numerous (15) class I alleles, alone or in conjunction with transporter protein variants, to homozygosity at the A or B locus, and to alleles of two class II haplotypes. A prognostic scoring algorithm derived from the 3 cohorts captured multiple HLA contributions to protection or to risk (relative hazard=0.57-60 per unit increase in score, all P<<.001). The impact of HLA was strong and appeared independent of the effects of chemokine receptor/ligand polymorphisms and antiretroviral treatment. The algorithm also predicted divergent rates of CD4+ cell decline in 2 other groups, totaling 227 seropositive persons (P=.06 - <.001). Confirmation of these relationships should encourage investigation of HIV-1 antigen processing and presentation mediated by polymorphisms in the HLA region.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-1899
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
180
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
299-309
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:10395843-Adult,
pubmed-meshheading:10395843-Algorithms,
pubmed-meshheading:10395843-Antigen Presentation,
pubmed-meshheading:10395843-CD4 Lymphocyte Count,
pubmed-meshheading:10395843-Carrier Proteins,
pubmed-meshheading:10395843-Cohort Studies,
pubmed-meshheading:10395843-Disease Progression,
pubmed-meshheading:10395843-Genes, MHC Class I,
pubmed-meshheading:10395843-Genes, MHC Class II,
pubmed-meshheading:10395843-HIV Infections,
pubmed-meshheading:10395843-HIV Seropositivity,
pubmed-meshheading:10395843-HIV-1,
pubmed-meshheading:10395843-Histocompatibility Antigens Class I,
pubmed-meshheading:10395843-Histocompatibility Antigens Class II,
pubmed-meshheading:10395843-Homosexuality, Male,
pubmed-meshheading:10395843-Homozygote,
pubmed-meshheading:10395843-Humans,
pubmed-meshheading:10395843-Male
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Consistent associations of HLA class I and II and transporter gene products with progression of human immunodeficiency virus type 1 infection in homosexual men.
|
| pubmed:affiliation |
Municipal Health Service, Amsterdam, The Netherlands. Reneke@hcrg.nl
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Multicenter Study
|