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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6738
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pubmed:dateCreated |
1999-7-21
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pubmed:databankReference |
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pubmed:abstractText |
The signalling protein Wnt regulates transcription factors containing high-mobility-group (HMG) domains to direct decisions on cell fate during animal development. In Caenorhabditis elegans, the HMG-domain-containing repressor POP-1 distinguishes the fates of anterior daughter cells from their posterior sisters throughout development, and Wnt signalling downregulates POP-1 activity in one posterior daughter cell called E. Here we show that the genes mom-4 and lit-1 are also required to downregulate POP-1, not only in E but also in other posterior daughter cells. Consistent with action in a common pathway, mom-4 and lit-1 exhibit similar mutant phenotypes and encode components of the mitogen-activated protein kinase (MAPK) pathway that are homologous to vertebrate transforming-growth-factor-beta-activated kinase (TAK1) and NEMO-like kinase (NLK), respectively. Furthermore, MOM-4 and TAK1 bind related proteins that promote their kinase activities. We conclude that a MAPK-related pathway cooperates with Wnt signal transduction to downregulate POP-1 activity. These functions are likely to be conserved in vertebrates, as TAK1 and NLK can downregulate HMG-domain-containing proteins related to POP-1.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Caenorhabditis elegans Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/High Mobility Group Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/KCNQ1OT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 4,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/MAP kinase kinase kinase 7,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/NLK protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium Channels, Voltage-Gated,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TAB1 protein, MAPKKK activator...,
http://linkedlifedata.com/resource/pubmed/chemical/TAB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Wnt Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Zebrafish Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/lit-1 protein, C elegans,
http://linkedlifedata.com/resource/pubmed/chemical/pop-1 protein, C elegans
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
399
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
793-7
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:10391246-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:10391246-Amino Acid Sequence,
pubmed-meshheading:10391246-Animals,
pubmed-meshheading:10391246-Caenorhabditis elegans,
pubmed-meshheading:10391246-Caenorhabditis elegans Proteins,
pubmed-meshheading:10391246-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:10391246-Carrier Proteins,
pubmed-meshheading:10391246-Cell Line,
pubmed-meshheading:10391246-Cloning, Molecular,
pubmed-meshheading:10391246-DNA-Binding Proteins,
pubmed-meshheading:10391246-Down-Regulation,
pubmed-meshheading:10391246-Enzyme Activation,
pubmed-meshheading:10391246-Gene Expression Regulation, Developmental,
pubmed-meshheading:10391246-Genes, Helminth,
pubmed-meshheading:10391246-High Mobility Group Proteins,
pubmed-meshheading:10391246-Humans,
pubmed-meshheading:10391246-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:10391246-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:10391246-MAP Kinase Kinase 4,
pubmed-meshheading:10391246-MAP Kinase Kinase Kinases,
pubmed-meshheading:10391246-Membrane Proteins,
pubmed-meshheading:10391246-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:10391246-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10391246-Molecular Sequence Data,
pubmed-meshheading:10391246-Potassium Channels, Voltage-Gated,
pubmed-meshheading:10391246-Protein Kinases,
pubmed-meshheading:10391246-Protein-Serine-Threonine Kinases,
pubmed-meshheading:10391246-Proto-Oncogene Proteins,
pubmed-meshheading:10391246-Sequence Homology, Amino Acid,
pubmed-meshheading:10391246-Signal Transduction,
pubmed-meshheading:10391246-Wnt Proteins,
pubmed-meshheading:10391246-Zebrafish Proteins
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pubmed:year |
1999
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pubmed:articleTitle |
MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans.
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pubmed:affiliation |
Institute of Molecular Biology, University of Oregon, Eugene 97403, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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