| pubmed-article:10376599 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10376599 | lifeskim:mentions | umls-concept:C1704319 | lld:lifeskim |
| pubmed-article:10376599 | lifeskim:mentions | umls-concept:C0178784 | lld:lifeskim |
| pubmed-article:10376599 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
| pubmed-article:10376599 | lifeskim:mentions | umls-concept:C0025543 | lld:lifeskim |
| pubmed-article:10376599 | lifeskim:mentions | umls-concept:C0332479 | lld:lifeskim |
| pubmed-article:10376599 | lifeskim:mentions | umls-concept:C0162610 | lld:lifeskim |
| pubmed-article:10376599 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:10376599 | pubmed:issue | 6736 | lld:pubmed |
| pubmed-article:10376599 | pubmed:dateCreated | 1999-6-30 | lld:pubmed |
| pubmed-article:10376599 | pubmed:abstractText | The molecular controls governing organ shape are poorly understood. In the nematode Caenorhabditis elegans, the gonad acquires a U-shape by the directed migration of a specialized 'leader' cell, which is located at the tip of the growing gonadal 'arm'. The gon-1 gene is essential for gonadal morphogenesis: in gon-1 mutants, no arm elongation occurs and somatic gonadal structures are severely malformed. Here we report that gon-1 encodes a secreted protein with a metalloprotease domain and multiple thrombospondin type-1-like repeats. This motif architecture is typical of a small family of genes that include bovine procollagen I N-protease (P1NP), which cleaves collagen, and murine ADAMTS-1, the expression of which correlates with tumour cell progression. We find that gon-1 is expressed in two sites, leader cells and muscle, and that expression in each site has a unique role in forming the gonad. We speculate that GON-1 controls morphogenesis by remodelling basement membranes and that regulation of its activity is crucial for achieving organ shape. | lld:pubmed |
| pubmed-article:10376599 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10376599 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10376599 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10376599 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10376599 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10376599 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10376599 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10376599 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10376599 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10376599 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:10376599 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:10376599 | pubmed:author | pubmed-author:KimbleJJ | lld:pubmed |
| pubmed-article:10376599 | pubmed:author | pubmed-author:BlellochRR | lld:pubmed |
| pubmed-article:10376599 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10376599 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:10376599 | pubmed:volume | 399 | lld:pubmed |
| pubmed-article:10376599 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10376599 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10376599 | pubmed:pagination | 586-90 | lld:pubmed |
| pubmed-article:10376599 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:meshHeading | pubmed-meshheading:10376599... | lld:pubmed |
| pubmed-article:10376599 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10376599 | pubmed:articleTitle | Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans. | lld:pubmed |
| pubmed-article:10376599 | pubmed:affiliation | Program in Cell and Molecular Biology, University of Wisconsin-Madison, 53706, USA. | lld:pubmed |
| pubmed-article:10376599 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10376599 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10376599 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10376599 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:177850 | entrezgene:pubmed | pubmed-article:10376599 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10376599 | lld:pubmed |
