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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6736
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pubmed:dateCreated |
1999-6-30
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pubmed:abstractText |
The molecular controls governing organ shape are poorly understood. In the nematode Caenorhabditis elegans, the gonad acquires a U-shape by the directed migration of a specialized 'leader' cell, which is located at the tip of the growing gonadal 'arm'. The gon-1 gene is essential for gonadal morphogenesis: in gon-1 mutants, no arm elongation occurs and somatic gonadal structures are severely malformed. Here we report that gon-1 encodes a secreted protein with a metalloprotease domain and multiple thrombospondin type-1-like repeats. This motif architecture is typical of a small family of genes that include bovine procollagen I N-protease (P1NP), which cleaves collagen, and murine ADAMTS-1, the expression of which correlates with tumour cell progression. We find that gon-1 is expressed in two sites, leader cells and muscle, and that expression in each site has a unique role in forming the gonad. We speculate that GON-1 controls morphogenesis by remodelling basement membranes and that regulation of its activity is crucial for achieving organ shape.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
399
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
586-90
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10376599-Amino Acid Sequence,
pubmed-meshheading:10376599-Animals,
pubmed-meshheading:10376599-Animals, Genetically Modified,
pubmed-meshheading:10376599-Caenorhabditis elegans,
pubmed-meshheading:10376599-Caenorhabditis elegans Proteins,
pubmed-meshheading:10376599-Chromosome Mapping,
pubmed-meshheading:10376599-Cloning, Molecular,
pubmed-meshheading:10376599-Female,
pubmed-meshheading:10376599-Gene Expression,
pubmed-meshheading:10376599-Genes, Helminth,
pubmed-meshheading:10376599-Gonads,
pubmed-meshheading:10376599-Helminth Proteins,
pubmed-meshheading:10376599-Male,
pubmed-meshheading:10376599-Metalloendopeptidases,
pubmed-meshheading:10376599-Molecular Sequence Data,
pubmed-meshheading:10376599-Morphogenesis,
pubmed-meshheading:10376599-Mutagenesis, Site-Directed,
pubmed-meshheading:10376599-Sequence Homology, Amino Acid,
pubmed-meshheading:10376599-Thrombospondin 1,
pubmed-meshheading:10376599-Transgenes
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pubmed:year |
1999
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pubmed:articleTitle |
Control of organ shape by a secreted metalloprotease in the nematode Caenorhabditis elegans.
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pubmed:affiliation |
Program in Cell and Molecular Biology, University of Wisconsin-Madison, 53706, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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