rdf:type |
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017280,
umls-concept:C0019704,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0030685,
umls-concept:C0042760,
umls-concept:C0185117,
umls-concept:C0332303,
umls-concept:C0391871,
umls-concept:C0521026,
umls-concept:C0680063,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1332714,
umls-concept:C1963578,
umls-concept:C2911684
|
pubmed:issue |
12
|
pubmed:dateCreated |
1999-8-20
|
pubmed:abstractText |
The human immunodeficiency virus type 1 (HIV-1) Nef protein is required for efficient virus replication in vivo and displays a number of distinct and apparently unrelated biological activities in vitro. Of these, one of the most readily demonstrated is the efficient internalization and degradation of cell-surface CD4, the receptor for the HIV-1 envelope protein. The biological purpose of this internalization has, however, remained unclear.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0960-9822
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
17
|
pubmed:volume |
9
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
613-21
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:10375525-Antigens, CD4,
pubmed-meshheading:10375525-Antigens, CD8,
pubmed-meshheading:10375525-Cell Line,
pubmed-meshheading:10375525-Down-Regulation,
pubmed-meshheading:10375525-Gene Expression,
pubmed-meshheading:10375525-Gene Products, env,
pubmed-meshheading:10375525-Gene Products, nef,
pubmed-meshheading:10375525-Genes, nef,
pubmed-meshheading:10375525-HIV Infections,
pubmed-meshheading:10375525-HIV-1,
pubmed-meshheading:10375525-Humans,
pubmed-meshheading:10375525-Transfection,
pubmed-meshheading:10375525-Virus Replication,
pubmed-meshheading:10375525-nef Gene Products, Human Immunodeficiency Virus,
pubmed-meshheading:10375525-src Homology Domains
|
pubmed:year |
1999
|
pubmed:articleTitle |
Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein.
|
pubmed:affiliation |
Yerkes Regional Primate Research Center, Division of Microbiology and Immunology, Emory University, Atlanta, Georgia 30329, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|