Source:http://linkedlifedata.com/resource/umls/id/C0017280
MSH: Products of the retroviral NEF GENE. They play a role as accessory proteins that influence the rate of viral infectivity and the destruction of the host immune system. nef gene products were originally found as factors that trans-suppress viral replication and function as negative regulators of transcription. nef stands for negative factor.,NCI: An integral component of HIV-1 particles. Nef facilitates a step in the viral life cycle occurring between penetration and reverse transcription (Aiken. Virology 1998; 248:139-147)