pubmed-article:10372996 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:10372996 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
pubmed-article:10372996 | lifeskim:mentions | umls-concept:C0021758 | lld:lifeskim |
pubmed-article:10372996 | lifeskim:mentions | umls-concept:C1705079 | lld:lifeskim |
pubmed-article:10372996 | lifeskim:mentions | umls-concept:C0079633 | lld:lifeskim |
pubmed-article:10372996 | lifeskim:mentions | umls-concept:C2330894 | lld:lifeskim |
pubmed-article:10372996 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
pubmed-article:10372996 | lifeskim:mentions | umls-concept:C1337092 | lld:lifeskim |
pubmed-article:10372996 | lifeskim:mentions | umls-concept:C1522558 | lld:lifeskim |
pubmed-article:10372996 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
pubmed-article:10372996 | pubmed:issue | 5 | lld:pubmed |
pubmed-article:10372996 | pubmed:dateCreated | 1999-7-27 | lld:pubmed |
pubmed-article:10372996 | pubmed:abstractText | Human retinal pigment epithelial (HRPE) cells are involved in ocular inflammation by secretion of chemokines such as IL-8 and MCP-1. It has been shown in this and other laboratories that interleukin-1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) are potent inducers of HRPE IL-8 and MCP-1 secretion. The induced IL-8 and MCP-1 expression is often modulated by other proinflammatory factors in a synergistic manner. Modulation of IL-8 and MCP-1 production by interleukin-4 (IL-4), a important mediator in Th2-mediated immunity, and granulocyte/macrophage-colony-stimulating factor (GM-CSF), one of the cytokines secreted by HRPE has been reported in non-ocular cells. The aim of the present investigation was to study effects of these two cytokines alone or in combination with IL-1beta or TNF-alpha on HRPE IL-8 and MCP-1 generation. | lld:pubmed |
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pubmed-article:10372996 | pubmed:language | eng | lld:pubmed |
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pubmed-article:10372996 | pubmed:citationSubset | IM | lld:pubmed |
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pubmed-article:10372996 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:10372996 | pubmed:month | May | lld:pubmed |
pubmed-article:10372996 | pubmed:issn | 0271-3683 | lld:pubmed |
pubmed-article:10372996 | pubmed:author | pubmed-author:ElnerV MVM | lld:pubmed |
pubmed-article:10372996 | pubmed:author | pubmed-author:KunkelS LSL | lld:pubmed |
pubmed-article:10372996 | pubmed:author | pubmed-author:StrieterR MRM | lld:pubmed |
pubmed-article:10372996 | pubmed:author | pubmed-author:ElnerS GSG | lld:pubmed |
pubmed-article:10372996 | pubmed:author | pubmed-author:LukacsN WNW | lld:pubmed |
pubmed-article:10372996 | pubmed:author | pubmed-author:BianZ MZM | lld:pubmed |
pubmed-article:10372996 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:10372996 | pubmed:volume | 18 | lld:pubmed |
pubmed-article:10372996 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:10372996 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:10372996 | pubmed:pagination | 349-57 | lld:pubmed |
pubmed-article:10372996 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:10372996 | pubmed:year | 1999 | lld:pubmed |
pubmed-article:10372996 | pubmed:articleTitle | IL-4 potentiates IL-1beta- and TNF-alpha-stimulated IL-8 and MCP-1 protein production in human retinal pigment epithelial cells. | lld:pubmed |
pubmed-article:10372996 | pubmed:affiliation | Department of Ophthalmology, University of Michigan, Ann Arbor 48105, USA. | lld:pubmed |
pubmed-article:10372996 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:10372996 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:10372996 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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