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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1999-7-27
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pubmed:abstractText |
Human retinal pigment epithelial (HRPE) cells are involved in ocular inflammation by secretion of chemokines such as IL-8 and MCP-1. It has been shown in this and other laboratories that interleukin-1 beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) are potent inducers of HRPE IL-8 and MCP-1 secretion. The induced IL-8 and MCP-1 expression is often modulated by other proinflammatory factors in a synergistic manner. Modulation of IL-8 and MCP-1 production by interleukin-4 (IL-4), a important mediator in Th2-mediated immunity, and granulocyte/macrophage-colony-stimulating factor (GM-CSF), one of the cytokines secreted by HRPE has been reported in non-ocular cells. The aim of the present investigation was to study effects of these two cytokines alone or in combination with IL-1beta or TNF-alpha on HRPE IL-8 and MCP-1 generation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0271-3683
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
349-57
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10372996-Cells, Cultured,
pubmed-meshheading:10372996-Chemokine CCL2,
pubmed-meshheading:10372996-Drug Combinations,
pubmed-meshheading:10372996-Drug Synergism,
pubmed-meshheading:10372996-Gene Expression,
pubmed-meshheading:10372996-Granulocyte-Macrophage Colony-Stimulating Factor,
pubmed-meshheading:10372996-Humans,
pubmed-meshheading:10372996-Interleukin-1,
pubmed-meshheading:10372996-Interleukin-4,
pubmed-meshheading:10372996-Interleukin-8,
pubmed-meshheading:10372996-Pigment Epithelium of Eye,
pubmed-meshheading:10372996-Tumor Necrosis Factor-alpha
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pubmed:year |
1999
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pubmed:articleTitle |
IL-4 potentiates IL-1beta- and TNF-alpha-stimulated IL-8 and MCP-1 protein production in human retinal pigment epithelial cells.
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pubmed:affiliation |
Department of Ophthalmology, University of Michigan, Ann Arbor 48105, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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