Linked Life Data

10371675

Source:http://linkedlifedata.com/resource/pubmed/id/10371675

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-7-16
pubmed:abstractText
The secretion of cytokines such as tumor necrosis factor alpha (TNFalpha) and interleukin-1 (IL-1) during immune activation induces sickness behavior. We have previously demonstrated that administration of either lipopolysaccharide (LPS) or IL-1 suppresses sexual behavior in female, but not in male rats. In the present study we sought to determine some of the mechanisms that are involved in mediating the alterations of female sexual behavior during immune activation. We report that sexual motivation of estrous females was reduced by intracerebroventricular administration of either recombinant rat (rr)TNFalpha (7.5 microg/rat) or rrIL-1beta (100 ng/rat), whereas sexual receptivity was altered only by IL-1beta. A significant reduction of both sexual motivation and receptivity was also induced by the combined administration of subthreshold doses of TNFalpha (3 microg/rat) and IL-1beta (20 ng/rat). These findings indicate that TNFalpha and IL-1beta act synergistically to suppress sexual motivation and receptivity. Moreover, LPS (100 microg/kg, ip)-induced reduction of sexual motivation was antagonized by the combined administration of the TNFalpha synthesis blocker pentoxifylline (50 mg/kg, ip) and IL-1 receptor antagonist (10 mg/kg, ip), but not by the administration of each of these substances by itself. In contrast, LPS-induced reduction of sexual receptivity was completely prevented by pentoxifylline. These findings indicate that the effects of LPS on sexual motivation are mediated by the synergistic effects of TNFalpha and IL-1, but only TNFalpha is required for the effect of LPS on receptivity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0889-1591
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Academic Press.
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Cytokines inhibit sexual behavior in female rats: I. Synergistic effects of tumor necrosis factor alpha and interleukin-1.
pubmed:affiliation
Department of Psychology, The Hebrew University of Jerusalem, Mount Scopus, Jerusalem, 91905, Israel.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't