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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1999-7-23
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pubmed:abstractText |
There have been many studies attempting to identify genes that determine susceptibility to primary biliary cirrhosis (PBC), but few studies have attempted to define the genes that modulate the natural history of the disease. There is a biallelic polymorphism, coined TNF1 and TNF2, in the TNFalpha promoter region at -308. We investigated the relative frequency of the TNF1 and TNF2 alleles in patients with PBC, based on the hypothesis that a polymorphism of the TNFalpha promoter region may be associated with the rate of progression and prognosis of PBC.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0168-8278
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
826-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10365808-Alleles,
pubmed-meshheading:10365808-California,
pubmed-meshheading:10365808-DNA,
pubmed-meshheading:10365808-Disease Progression,
pubmed-meshheading:10365808-European Continental Ancestry Group,
pubmed-meshheading:10365808-Genotype,
pubmed-meshheading:10365808-Germany,
pubmed-meshheading:10365808-Heterozygote Detection,
pubmed-meshheading:10365808-Homozygote,
pubmed-meshheading:10365808-Humans,
pubmed-meshheading:10365808-Italy,
pubmed-meshheading:10365808-Liver Cirrhosis, Biliary,
pubmed-meshheading:10365808-Odds Ratio,
pubmed-meshheading:10365808-Polymerase Chain Reaction,
pubmed-meshheading:10365808-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:10365808-Promoter Regions, Genetic,
pubmed-meshheading:10365808-Reference Values,
pubmed-meshheading:10365808-Tumor Necrosis Factor-alpha,
pubmed-meshheading:10365808-Victoria
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pubmed:year |
1999
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pubmed:articleTitle |
The tumor necrosis factor-alpha promoter correlates with progression of primary biliary cirrhosis.
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pubmed:affiliation |
Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis, 95616-8660, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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