Linked Life Data

10361228

Source:http://linkedlifedata.com/resource/pubmed/id/10361228

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-6-23
pubmed:abstractText
The adoptive transfer of activated CD4+ alpha/beta T cell blasts from the spleens of immunocompetent C.B-17+/+ or BALB/cdm2 mice into C.B-17scid/scid (scid) mice induces a colitis in the scid recipient within 8 weeks, which progresses to severe disease within 16 weeks. T cells isolated from recipient colon show a Th1 cytokine phenotype. We have examined the relationship between the phenotype of the cellular infiltrate and the transcription and translation of the proinflammatory cytokine TNF-alpha. The techniques of double indirect immunohistology and in situ hybridization using digoxigenin-labelled riboprobes were used. The prominent myeloid cell infiltrate in diseased tissues comprised F4/80+, Mac-l+ macrophages, neutrophils, dendritic cells and activated macrophages. TNF-alpha transcription and translation were associated with activated macrophages in the lamina propria. Activated macrophages transcribing and translating TNF-alpha were clustered in areas of tissue destruction. Crypt epithelium of inflamed tissues transcribed TNF-alpha at a very early stage of the disease process, but translation of TNF-alpha protein could only be found in advanced epithelial dysplasia. This indicates differential post-transcriptional control of TNF-alpha in activated macrophages and the epithelium.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-1427374, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-1587185, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-1590993, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-1712071, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-1885073, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-1940369, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-2010550, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-2038332, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-2117510, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-2419912, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-271968, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-2828427, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-3488815, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-6260957, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-6355361, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-7019381, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-7600284, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-7638751, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-7701110, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-7814646, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-7841354, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-7903159, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-7905019, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-7957572, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-8031350, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-8100269, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-8327860, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-8402910, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-8402911, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-8550607, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-8623920, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-8647179, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-8647181, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-8676088, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-8977307, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-9013944, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-9029093, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-9048788, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-9176073, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-9176074, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-9244305, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-9247586, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-9321530, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-9338786, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-9485217, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-9521083, http://linkedlifedata.com/resource/pubmed/commentcorrection/10361228-9536936
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
116
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
415-24
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Tumour necrosis factor-alpha (TNF-alpha) transcription and translation in the CD4+ T cell-transplanted scid mouse model of colitis.
pubmed:affiliation
Division of Molecular and Cellular Biology, University of Bristol, Bristol, UK. Amanda.Williams@Bris.ac.UK
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't