| pubmed-article:10356364 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10356364 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10356364 | lifeskim:mentions | umls-concept:C0887899 | lld:lifeskim |
| pubmed-article:10356364 | lifeskim:mentions | umls-concept:C0079784 | lld:lifeskim |
| pubmed-article:10356364 | lifeskim:mentions | umls-concept:C0080092 | lld:lifeskim |
| pubmed-article:10356364 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:10356364 | lifeskim:mentions | umls-concept:C0282625 | lld:lifeskim |
| pubmed-article:10356364 | lifeskim:mentions | umls-concept:C0596988 | lld:lifeskim |
| pubmed-article:10356364 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10356364 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:10356364 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10356364 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10356364 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10356364 | pubmed:dateCreated | 2000-8-28 | lld:pubmed |
| pubmed-article:10356364 | pubmed:abstractText | We have established two M1 myeloid cell lines, M1/WT cells overexpressing the wild-type CSF-1 receptor and M1/Y559F cells expressing a specific tyrosine mutant. M1/WT cells differentiated in response to CSF-1, with a reduction in their proliferative capacity. CSF-1-mediated differentiation was partially abrogated in the M1/Y559F cells, with a less marked reduction in proliferative capacity. The Src tyrosine kinases c-Src, c-Yes, c-Fyn, and c-Hck were tyrosine phosphorylated in the M1/WT cells in response to CSF-1 and bound to the WT CSF-1R through their SH2 domains. Binding of the Src kinases to the CSF-1 receptor was greatly reduced in the M1/Y559F cells. CSF-1-mediated activation of STAT3 was also abrogated in the M1/Y559F cell line. Treatment of M1/WT cells with the Src family inhibitor PP2 resulted in an inhibition of CSF-1-mediated differentiation, equivalent to that observed in the M1/Y559F cells. These data suggest that the reduced Src binding observed in the M1/Y559F cells may contribute to their reduced ability to differentiate. | lld:pubmed |
| pubmed-article:10356364 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10356364 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10356364 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10356364 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10356364 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10356364 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10356364 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10356364 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10356364 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10356364 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10356364 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10356364 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10356364 | pubmed:month | May | lld:pubmed |
| pubmed-article:10356364 | pubmed:issn | 1522-4724 | lld:pubmed |
| pubmed-article:10356364 | pubmed:author | pubmed-author:NovakUU | lld:pubmed |
| pubmed-article:10356364 | pubmed:author | pubmed-author:HamiltonJ AJA | lld:pubmed |
| pubmed-article:10356364 | pubmed:author | pubmed-author:WardA CAC | lld:pubmed |
| pubmed-article:10356364 | pubmed:author | pubmed-author:MarksD CDC | lld:pubmed |
| pubmed-article:10356364 | pubmed:author | pubmed-author:WilsonN JNJ | lld:pubmed |
| pubmed-article:10356364 | pubmed:author | pubmed-author:CsarX FXF | lld:pubmed |
| pubmed-article:10356364 | pubmed:author | pubmed-author:HoffmannB WBW | lld:pubmed |
| pubmed-article:10356364 | pubmed:author | pubmed-author:Kanagasundaru... | lld:pubmed |
| pubmed-article:10356364 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10356364 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:10356364 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10356364 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10356364 | pubmed:pagination | 144-52 | lld:pubmed |
| pubmed-article:10356364 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:10356364 | pubmed:meshHeading | pubmed-meshheading:10356364... | lld:pubmed |
| pubmed-article:10356364 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10356364 | pubmed:articleTitle | Expression of a Y559F mutant CSF-1 receptor in M1 myeloid cells: a role for Src kinases in CSF-1 receptor-mediated differentiation. | lld:pubmed |
| pubmed-article:10356364 | pubmed:affiliation | Inflammation Research Centre, Department of Medicine, University of Melbourne, Parkville, Victoria, Australia. x.csar@medicine.unimelb.edu.au | lld:pubmed |
| pubmed-article:10356364 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10356364 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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