Linked Life Data

10354374

Source:http://linkedlifedata.com/resource/pubmed/id/10354374

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1999-7-13
pubmed:abstractText
Mononuclear cell subsets in 25 human umbilical cord blood samples and 10 healthy adults were studied. We found a decreased percentage of CD3+ cells, CD8+ cells and gammadelta T cells in cord blood compared with blood from healthy adults. The CD16+56+ and CD19+CD5+ phenotypes were overexpressed in cord blood. We then measured spontaneous gene expression and the production of interleukin-10 in mononuclear cells from cord blood and adult subjects. Although we found no difference between cord blood cells and those from healthy adults, a tendency towards spontaneous interleukin-10 production was observed in cord blood. Phorbol 12-myristate 13-acetate stimulation revealed that, among lymphocytes, cord blood B cells are the main cellular source of interleukin-10. Finally, we found no evidence of augmented spontaneous apoptosis but an increased bcl-2 gene expression in non-T cells from cord blood. Interleukin-10 might protect CD19+CD5+ B cells from apoptosis by inducing bcl-2 and promoting autoantibody production in this B-cell subpopulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0300-9475
pubmed:author
pubmed:issnType
Print
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
629-32
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Possible role of interleukin-10 in autoantibody production and in the fate of human cord blood CD5+ B lymphocytes.
pubmed:affiliation
Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't