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rdf:type |
|
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lifeskim:mentions |
umls-concept:C0007586,
umls-concept:C0007589,
umls-concept:C0017262,
umls-concept:C0021666,
umls-concept:C0028778,
umls-concept:C0185117,
umls-concept:C0205390,
umls-concept:C0282560,
umls-concept:C1280500,
umls-concept:C1511938,
umls-concept:C2911684
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|
pubmed:issue |
6
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|
pubmed:dateCreated |
1999-6-30
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|
pubmed:abstractText |
We have previously shown that autocrine insulin-like growth factor (IGF)-II synthesis through IGF-I receptor stimulates proliferation and inhibits differentiation of Caco-2 cells. To demonstrate whether differentiation of Caco-2 cells is dependent on cell growth status, we analyzed the effect of cell cycle arrest on differentiation of wild-type and IGF-II-overexpressing cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0016-5085
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1358-66
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10348819-Anti-Bacterial Agents,
pubmed-meshheading:10348819-Caco-2 Cells,
pubmed-meshheading:10348819-Cell Cycle,
pubmed-meshheading:10348819-Cell Differentiation,
pubmed-meshheading:10348819-Cell Division,
pubmed-meshheading:10348819-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:10348819-Cyclins,
pubmed-meshheading:10348819-Cytarabine,
pubmed-meshheading:10348819-Drug Resistance, Microbial,
pubmed-meshheading:10348819-G1 Phase,
pubmed-meshheading:10348819-G2 Phase,
pubmed-meshheading:10348819-Humans,
pubmed-meshheading:10348819-Insulin-Like Growth Factor II,
pubmed-meshheading:10348819-Intestinal Mucosa,
pubmed-meshheading:10348819-Neomycin,
pubmed-meshheading:10348819-Nocodazole,
pubmed-meshheading:10348819-Ploidies,
pubmed-meshheading:10348819-Retinoblastoma Protein,
pubmed-meshheading:10348819-Transfection
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pubmed:year |
1999
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pubmed:articleTitle |
Cell cycle block at G1-S or G2-M phase correlates with differentiation of Caco-2 cells: effect of constitutive insulin-like growth factor II expression.
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pubmed:affiliation |
Centro di Endocrinologia ed Oncologia Sperimentale del Consiglio Nazionale delle Ricerche "G. Salvatore," Dipartimento di Biologia e Patologia Cellulare e Molecolare "L. Califano, Naples, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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