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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1999-6-23
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pubmed:abstractText |
To evaluate if atovaquone (ATQ) interacts pharmacokinetically with azithromycin (AZ) in human immunodeficiency virus-infected children, 10 subjects (ages, 4 to 13 years) were randomized in a crossover study to receive AZ (5 mg/kg/day) alone (ALONE) or AZ (5 mg/kg/day) and ATQ (30 mg/kg/day) simultaneously (SIM) prior to receiving AZ and ATQ staggered by 12 h. Despite a lack of significant difference in the mean AZ pharmacokinetic parameters, the steady-state values of AZ's area under the concentration-time curve from 0 to 24 h and maximum concentration in serum were consistently lower (n = 7 of 7) for the SIM regimen than they were for the ALONE regimen. A larger study will be required to determine if ATQ affects AZ pharmacokinetics and efficacy in a clinically significant manner.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-1349667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-1352871,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-1656740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-1662631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-1662633,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-1722460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-1881738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-1963411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-2154441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-2154442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-2235185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-2594038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-7486938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-8222520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-8383944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-8479489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-8634356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-9209246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10348786-9624466
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1516-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10348786-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10348786-Adolescent,
pubmed-meshheading:10348786-Anti-Bacterial Agents,
pubmed-meshheading:10348786-Antifungal Agents,
pubmed-meshheading:10348786-Atovaquone,
pubmed-meshheading:10348786-Azithromycin,
pubmed-meshheading:10348786-Child,
pubmed-meshheading:10348786-Child, Preschool,
pubmed-meshheading:10348786-Cross-Over Studies,
pubmed-meshheading:10348786-Drug Interactions,
pubmed-meshheading:10348786-HIV-1,
pubmed-meshheading:10348786-Humans,
pubmed-meshheading:10348786-Naphthoquinones
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pubmed:year |
1999
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pubmed:articleTitle |
Pharmacokinetics of azithromycin administered alone and with atovaquone in human immunodeficiency virus-infected children. The ACTG 254 Team.
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pubmed:affiliation |
Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, USA.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial
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