rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
1999-7-21
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pubmed:abstractText |
The Drosophila Notch protein is a receptor that controls cell fate during embryonic development, particularly in lateral inhibition, a process that acts on groups of cells that share a particular developmental potential to restrict the number of cells that will adopt that cell fate. The process of lateral inhibition is implemented by the nuclear protein Suppressor of Hairless (Su(H)) and is triggered by the ligand Delta. Recent results have shown that the interaction between Delta and Notch triggers the cleavage of the intracellular domain of Notch which then translocates to the nucleus and binds to Su(H).
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Drosophila Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Notch,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/notch protein, Drosophila,
http://linkedlifedata.com/resource/pubmed/chemical/suppressor of Hairless protein...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
460-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10322111-Animals,
pubmed-meshheading:10322111-Binding Sites,
pubmed-meshheading:10322111-Body Patterning,
pubmed-meshheading:10322111-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:10322111-Drosophila,
pubmed-meshheading:10322111-Drosophila Proteins,
pubmed-meshheading:10322111-Intracellular Fluid,
pubmed-meshheading:10322111-JNK Mitogen-Activated Protein Kinases,
pubmed-meshheading:10322111-Membrane Proteins,
pubmed-meshheading:10322111-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10322111-Mutagenesis,
pubmed-meshheading:10322111-Phosphorylation,
pubmed-meshheading:10322111-Receptors, Notch,
pubmed-meshheading:10322111-Repressor Proteins,
pubmed-meshheading:10322111-Signal Transduction
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pubmed:year |
1999
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pubmed:articleTitle |
An activity of Notch regulates JNK signalling and affects dorsal closure in Drosophila.
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pubmed:affiliation |
Department of Zoology University of Cambridge Cambridge, CB2 3EJ, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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