| pubmed-article:10233758 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10233758 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:10233758 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10233758 | lifeskim:mentions | umls-concept:C0085295 | lld:lifeskim |
| pubmed-article:10233758 | lifeskim:mentions | umls-concept:C0021755 | lld:lifeskim |
| pubmed-article:10233758 | lifeskim:mentions | umls-concept:C1456820 | lld:lifeskim |
| pubmed-article:10233758 | lifeskim:mentions | umls-concept:C1704264 | lld:lifeskim |
| pubmed-article:10233758 | lifeskim:mentions | umls-concept:C1706001 | lld:lifeskim |
| pubmed-article:10233758 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:10233758 | lifeskim:mentions | umls-concept:C1363984 | lld:lifeskim |
| pubmed-article:10233758 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:10233758 | lifeskim:mentions | umls-concept:C0449450 | lld:lifeskim |
| pubmed-article:10233758 | lifeskim:mentions | umls-concept:C0002131 | lld:lifeskim |
| pubmed-article:10233758 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:10233758 | pubmed:dateCreated | 1999-6-18 | lld:pubmed |
| pubmed-article:10233758 | pubmed:abstractText | Cytokines induced in skin by ultraviolet radiation cause local and systemic immunosuppression. Tumor necrosis factor alpha, interleukin-1, and interleukin-10 are key mediators in the mouse, but less is known about cytokine synthesis and function in ultraviolet-irradiated human skin. We exposed human skin to 3 minimal erythema doses of solar-simulated radiation and raised suction blisters at intervals to 72 h. Alloantigen presentation was suppressed in a mixed epidermal cell-lymphocyte reaction by 69% from 4 to 15 h post-solar-simulated radiation, but recovered to control values by 24 h. Tumor necrosis factor alpha was raised at 4 h after solar-simulated radiation, reached a maximum 8-fold increase at 15 h, then rapidly declined to control values. Interleukin-1alpha and interleukin-1beta were first increased at 15 h, and remained raised to 72 h, although interleukin-1beta declined from its 15 h maximum. Interleukin-10 increased a maximum 2-fold between 15 and 24 h, coincident with recovery of mixed epidermal cell-lymphocyte reaction responses and downregulation of tumor necrosis factor alpha and interleukin-1beta. Solar-simulated radiation differentially affected soluble tumor necrosis factor alpha receptors; soluble tumor necrosis factor-RI was suppressed 33% at 8-15 h whereas soluble tumor necrosis factor-RII increased 2-fold from 15 to 48 h. Interleukin-1 receptor antagonist was raised at all times post-irradiation. Interleukin-12 was not detectable in control or irradiated skin. These kinetics suggest the tumor necrosis factor alpha network has primary importance in ultraviolet-damaged human skin. The small increase in interleukin-10 implies that 3 minimal erythema doses of solar-simulated radiation is the threshold dose for its induction and local, rather than systemic, functions for interleukin-10 in immunosuppression and regulation of other cytokines. | lld:pubmed |
| pubmed-article:10233758 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10233758 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233758 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10233758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233758 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10233758 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10233758 | pubmed:month | May | lld:pubmed |
| pubmed-article:10233758 | pubmed:issn | 0022-202X | lld:pubmed |
| pubmed-article:10233758 | pubmed:author | pubmed-author:GreavesM WMW | lld:pubmed |
| pubmed-article:10233758 | pubmed:author | pubmed-author:YoungA RAR | lld:pubmed |
| pubmed-article:10233758 | pubmed:author | pubmed-author:BarrR MRM | lld:pubmed |
| pubmed-article:10233758 | pubmed:author | pubmed-author:WalkerS LSL | lld:pubmed |
| pubmed-article:10233758 | pubmed:author | pubmed-author:HarrisonG IGI | lld:pubmed |
| pubmed-article:10233758 | pubmed:author | pubmed-author:TsangWW | lld:pubmed |
| pubmed-article:10233758 | pubmed:author | pubmed-author:EttehadiPP | lld:pubmed |
| pubmed-article:10233758 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10233758 | pubmed:volume | 112 | lld:pubmed |
| pubmed-article:10233758 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10233758 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10233758 | pubmed:pagination | 692-8 | lld:pubmed |
| pubmed-article:10233758 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:10233758 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10233758 | pubmed:articleTitle | Suppressed alloantigen presentation, increased TNF-alpha, IL-1, IL-1Ra, IL-10, and modulation of TNF-R in UV-irradiated human skin. | lld:pubmed |
| pubmed-article:10233758 | pubmed:affiliation | St John's Institute of Dermatology, Guy's, King's, and St Thomas' School of Medicine, King's College London, St Thomas' Hospital, London, UK. | lld:pubmed |
| pubmed-article:10233758 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10233758 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10233758 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10233758 | lld:pubmed |
