Source:http://linkedlifedata.com/resource/pubmed/id/10233758
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1999-6-18
|
| pubmed:abstractText |
Cytokines induced in skin by ultraviolet radiation cause local and systemic immunosuppression. Tumor necrosis factor alpha, interleukin-1, and interleukin-10 are key mediators in the mouse, but less is known about cytokine synthesis and function in ultraviolet-irradiated human skin. We exposed human skin to 3 minimal erythema doses of solar-simulated radiation and raised suction blisters at intervals to 72 h. Alloantigen presentation was suppressed in a mixed epidermal cell-lymphocyte reaction by 69% from 4 to 15 h post-solar-simulated radiation, but recovered to control values by 24 h. Tumor necrosis factor alpha was raised at 4 h after solar-simulated radiation, reached a maximum 8-fold increase at 15 h, then rapidly declined to control values. Interleukin-1alpha and interleukin-1beta were first increased at 15 h, and remained raised to 72 h, although interleukin-1beta declined from its 15 h maximum. Interleukin-10 increased a maximum 2-fold between 15 and 24 h, coincident with recovery of mixed epidermal cell-lymphocyte reaction responses and downregulation of tumor necrosis factor alpha and interleukin-1beta. Solar-simulated radiation differentially affected soluble tumor necrosis factor alpha receptors; soluble tumor necrosis factor-RI was suppressed 33% at 8-15 h whereas soluble tumor necrosis factor-RII increased 2-fold from 15 to 48 h. Interleukin-1 receptor antagonist was raised at all times post-irradiation. Interleukin-12 was not detectable in control or irradiated skin. These kinetics suggest the tumor necrosis factor alpha network has primary importance in ultraviolet-damaged human skin. The small increase in interleukin-10 implies that 3 minimal erythema doses of solar-simulated radiation is the threshold dose for its induction and local, rather than systemic, functions for interleukin-10 in immunosuppression and regulation of other cytokines.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/IL1RN protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Il1rn protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin 1 Receptor Antagonist...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-10,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-12,
http://linkedlifedata.com/resource/pubmed/chemical/Isoantigens,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0022-202X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
112
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
692-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10233758-Adolescent,
pubmed-meshheading:10233758-Adult,
pubmed-meshheading:10233758-Antigens, CD,
pubmed-meshheading:10233758-Dose-Response Relationship, Radiation,
pubmed-meshheading:10233758-Down-Regulation,
pubmed-meshheading:10233758-Exudates and Transudates,
pubmed-meshheading:10233758-Female,
pubmed-meshheading:10233758-Humans,
pubmed-meshheading:10233758-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:10233758-Interleukin-1,
pubmed-meshheading:10233758-Interleukin-10,
pubmed-meshheading:10233758-Interleukin-12,
pubmed-meshheading:10233758-Isoantigens,
pubmed-meshheading:10233758-Male,
pubmed-meshheading:10233758-Middle Aged,
pubmed-meshheading:10233758-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:10233758-Receptors, Tumor Necrosis Factor, Type I,
pubmed-meshheading:10233758-Receptors, Tumor Necrosis Factor, Type II,
pubmed-meshheading:10233758-Sialoglycoproteins,
pubmed-meshheading:10233758-Skin,
pubmed-meshheading:10233758-Time Factors,
pubmed-meshheading:10233758-Tumor Necrosis Factor-alpha,
pubmed-meshheading:10233758-Ultraviolet Rays
|
| pubmed:year |
1999
|
| pubmed:articleTitle |
Suppressed alloantigen presentation, increased TNF-alpha, IL-1, IL-1Ra, IL-10, and modulation of TNF-R in UV-irradiated human skin.
|
| pubmed:affiliation |
St John's Institute of Dermatology, Guy's, King's, and St Thomas' School of Medicine, King's College London, St Thomas' Hospital, London, UK.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|