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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1999-6-30
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pubmed:abstractText |
The two highly conserved RAS genes of the budding yeast Saccharomyces cerevisiae are redundant for viability. Here we show that haploid invasive growth development depends on RAS2 but not RAS1. Ras1p is not sufficiently expressed to induce invasive growth. Ras2p activates invasive growth using either of two downstream signaling pathways, the filamentation MAPK (Cdc42p/Ste20p/MAPK) cascade or the cAMP-dependent protein kinase (Cyr1p/cAMP/PKA) pathway. This signal branch point can be uncoupled in cells expressing Ras2p mutant proteins that carry amino acid substitutions in the adenylyl cyclase interaction domain and therefore activate invasive growth solely dependent on the MAPK cascade. Both Ras2p-controlled signaling pathways stimulate expression of the filamentation response element-driven reporter gene depending on the transcription factors Ste12p and Tec1p, indicating a crosstalk between the MAPK and the cAMP signaling pathways in haploid cells during invasive growth.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-1425591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-1468625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-14731620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-1544568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-1820817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-1848378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-1904541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-2017169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-2040016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-2070413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-2155776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-2178777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-2192259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-2659436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-3036373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-3037314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-3073106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-3275878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-6235522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-6327067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-7479926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-7502049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-7657656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-8001818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-8034612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-8259520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-8524252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-8607982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-8621388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-8628998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-8643578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-8730867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-9036858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-9055077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-9252333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-9384580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-9393860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-9436998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-9482721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-9524122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10233147-9811878
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/FMN Reductase,
http://linkedlifedata.com/resource/pubmed/chemical/Fungal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/NADH, NADPH Oxidoreductases,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/RAS1 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/RAS2 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/STE12 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/STE20 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TEC1 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/cdc42 GTP-Binding Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/ferric citrate iron reductase,
http://linkedlifedata.com/resource/pubmed/chemical/ras Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1059-1524
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1325-35
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
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