Linked Life Data

10225371

Source:http://linkedlifedata.com/resource/pubmed/id/10225371

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-6-29
pubmed:abstractText
Previous investigations have shown subunit-selective alterations in NMDA receptors in ethanol dependent male rats. In the present study, we found pronounced gender differences in the effects of ethanol dependence on NMDA receptor subunit expression in all brain regions investigated. Ethanol dependent female rats exhibited increased NR1 subunit levels in cerebral cortex and hypothalamus, whereas males displayed increased NR1 levels only in hippocampus. NR2A subunit levels were significantly increased only in hippocampus from ethanol dependent male rats, whereas NR2B subunit levels significantly increased in cerebral cortex of both female and male rats. These findings suggest that gender influences neuroadaptations elicited by ethanol dependence at the level of NMDA receptor subunit expression.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
26
pubmed:volume
369
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-4
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Gender-selective effects of ethanol dependence on NMDA receptor subunit expression in cerebral cortex, hippocampus and hypothalamus.
pubmed:affiliation
Department of Pharmaceutical Sciences, College of Pharmacy, Idaho State University, Pocatello 83209-8334, USA. ldevaud@otc.isu.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.