| pubmed-article:10221672 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10221672 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:10221672 | lifeskim:mentions | umls-concept:C0007806 | lld:lifeskim |
| pubmed-article:10221672 | lifeskim:mentions | umls-concept:C0040688 | lld:lifeskim |
| pubmed-article:10221672 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:10221672 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10221672 | pubmed:dateCreated | 1999-7-6 | lld:pubmed |
| pubmed-article:10221672 | pubmed:abstractText | In this study, we investigated cerebrospinal fluid of patients with various neurological symptoms for the presence of transforming growth factor alpha (TGF-alpha). 41 samples of cerebrospinal fluid were collected by lumbar puncture performed routinely due to the clinical suspicion of neurological disease from 22 females (age 15-80 years, median 42 years) and from 19 males (age 18-82 years, median 48 years). A highly sensitive and specific radioimmunoassay was used to determine the concentration of TGF-alpha in the samples. The detection limit of the assay was about 200 pg TGF-alpha. There was no cross-reactivity to human EGF. We showed CSF indeed does contain TGFalpha. As TGF-alpha was detected in all 41 samples investigated, this growth factor appears to be a constant component of CSF. The mean concentration was 5.5 ng TGF-alpha (S.D. +/- 2.7 pg/ml, range 1.1 to 13.9 pg/ml). There was no significant correlation between TGF-alpha concentration in CSF and age (r = -0.006) and there was no significant difference between females (mean 5.8+/-3.10 pg/ml) and males (mean 5.2+/-1.96 pg/ml). No diagnosis was over represented in patients with TGF-alpha concentrations above or below 1 S.D. off the mean. However, highest concentrations of TGF-alpha were found in the group of patients with peripheral neurological sensory dysfunctions and polyneuropathy. We conclude that TGF-alpha is not only a constant component of human cerebrospinal fluid in adults but could also be significantly involved in the pathophysiology of various neurological diseases. The earlier hypothesis that TGF-alpha could mainly have a role in brain development needs hence to be re-evaluated. | lld:pubmed |
| pubmed-article:10221672 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10221672 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10221672 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10221672 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10221672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10221672 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10221672 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10221672 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10221672 | pubmed:issn | 0736-5748 | lld:pubmed |
| pubmed-article:10221672 | pubmed:author | pubmed-author:SchultzGG | lld:pubmed |
| pubmed-article:10221672 | pubmed:author | pubmed-author:StiblerHH | lld:pubmed |
| pubmed-article:10221672 | pubmed:author | pubmed-author:RasmussenSS | lld:pubmed |
| pubmed-article:10221672 | pubmed:author | pubmed-author:EdströmLL | lld:pubmed |
| pubmed-article:10221672 | pubmed:author | pubmed-author:Van SettenG... | lld:pubmed |
| pubmed-article:10221672 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10221672 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:10221672 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10221672 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10221672 | pubmed:pagination | 131-4 | lld:pubmed |
| pubmed-article:10221672 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:10221672 | pubmed:meshHeading | pubmed-meshheading:10221672... | lld:pubmed |
| pubmed-article:10221672 | pubmed:meshHeading | pubmed-meshheading:10221672... | lld:pubmed |
| pubmed-article:10221672 | pubmed:meshHeading | pubmed-meshheading:10221672... | lld:pubmed |
| pubmed-article:10221672 | pubmed:meshHeading | pubmed-meshheading:10221672... | lld:pubmed |
| pubmed-article:10221672 | pubmed:meshHeading | pubmed-meshheading:10221672... | lld:pubmed |
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| pubmed-article:10221672 | pubmed:meshHeading | pubmed-meshheading:10221672... | lld:pubmed |
| pubmed-article:10221672 | pubmed:meshHeading | pubmed-meshheading:10221672... | lld:pubmed |
| pubmed-article:10221672 | pubmed:meshHeading | pubmed-meshheading:10221672... | lld:pubmed |
| pubmed-article:10221672 | pubmed:meshHeading | pubmed-meshheading:10221672... | lld:pubmed |
| pubmed-article:10221672 | pubmed:meshHeading | pubmed-meshheading:10221672... | lld:pubmed |
| pubmed-article:10221672 | pubmed:meshHeading | pubmed-meshheading:10221672... | lld:pubmed |
| pubmed-article:10221672 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10221672 | pubmed:articleTitle | Levels of transforming growth factor alpha (TGF-alpha) in human cerebrospinal fluid. | lld:pubmed |
| pubmed-article:10221672 | pubmed:affiliation | St. Eriks Eye Clinic, Karolinska Institute, Stockholm, Sweden. | lld:pubmed |
| pubmed-article:10221672 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10221672 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:10221672 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10221672 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10221672 | lld:pubmed |
