| pubmed-article:10208841 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10208841 | lifeskim:mentions | umls-concept:C0225336 | lld:lifeskim |
| pubmed-article:10208841 | lifeskim:mentions | umls-concept:C0080194 | lld:lifeskim |
| pubmed-article:10208841 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:10208841 | lifeskim:mentions | umls-concept:C0752312 | lld:lifeskim |
| pubmed-article:10208841 | lifeskim:mentions | umls-concept:C0332157 | lld:lifeskim |
| pubmed-article:10208841 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10208841 | lifeskim:mentions | umls-concept:C0851827 | lld:lifeskim |
| pubmed-article:10208841 | lifeskim:mentions | umls-concept:C1701901 | lld:lifeskim |
| pubmed-article:10208841 | lifeskim:mentions | umls-concept:C0439596 | lld:lifeskim |
| pubmed-article:10208841 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:10208841 | pubmed:dateCreated | 1999-6-1 | lld:pubmed |
| pubmed-article:10208841 | pubmed:abstractText | Hemodynamic forces play a key role in the modulation of the morphology and function of the endothelium by activating several kinases. We have previously shown that cyclic strain, a repetitive mechanical stretch, induces activation of extracellular signal-regulated protein kinases 1 and 2 (ERK1/2), members of the mitogen activated protein (MAP) kinase family. In order to investigate the upstream pathway of strain-induced ERK1/2 activation, we examined p21ras activation by cyclic strain and the effect of wortmannin and LY294002, phosphatidylinositol-3 kinase (PI 3-kinase) inhibitors on ERK1/2 phosphorylation. Cyclic strain induced a transient and rapid activation of p21ras at 1 min after strain. Wortmannin inhibited strain-induced ERK1/2 activation by 56.3 and 86.3 %, respectively. LY294002 inhibited ERK1 activation completely and ERK2 activation by 42.9%. These results suggest a possible involvement of p21ras and PI 3-kinase in the signal transduction pathway leading to the strain-induced ERK1/2 activation. | lld:pubmed |
| pubmed-article:10208841 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10208841 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:10208841 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:10208841 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10208841 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:10208841 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:10208841 | pubmed:author | pubmed-author:IkedaMM | lld:pubmed |
| pubmed-article:10208841 | pubmed:author | pubmed-author:KitoHH | lld:pubmed |
| pubmed-article:10208841 | pubmed:author | pubmed-author:SumpioB EBE | lld:pubmed |
| pubmed-article:10208841 | pubmed:copyrightInfo | Copyright 1999 Academic Press. | lld:pubmed |
| pubmed-article:10208841 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10208841 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:10208841 | pubmed:volume | 257 | lld:pubmed |
| pubmed-article:10208841 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10208841 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10208841 | pubmed:pagination | 668-71 | lld:pubmed |
| pubmed-article:10208841 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:10208841 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:10208841 | pubmed:articleTitle | Phosphatidylinositol-3 kinase dependent MAP kinase activation via p21ras in endothelial cells exposed to cyclic strain. | lld:pubmed |
| pubmed-article:10208841 | pubmed:affiliation | Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, 06510, USA. | lld:pubmed |
| pubmed-article:10208841 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10208841 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:10208841 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:10208841 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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