Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1999-5-27
pubmed:abstractText
Teratogen-induced cell death is a common event in the pathogenesis associated with tissues destined to be malformed. Although the importance of this cell death is recognized, little information is available concerning the biochemistry of teratogen-induced cell death. We show that three teratogens, hyperthermia, cyclophosphamide and sodium arsenite induce an increase in cell death in day 9.0 mouse embryos with concurrent induction of DNA fragmentation, activation of caspase-3 and the cleavage of poly (ADP-ribose) polymerase (PARP). Teratogen-induced cell death is also selective, i. e., some cells within a tissue die while others survive. In addition, cells within some tissues die when exposed to teratogens while cells in other tissues are relatively resistant to teratogen-induced cell death. An example of the latter selectivity is seen in the cells of the developing heart, which are resistant to the cytotoxic potential of many teratogens. We show that the absence of cell death in the heart is accompanied by the complete lack of DNA fragmentation, activtion of caspase-3 and the cleavage of PARP.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1350-9047
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
592-600
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:10200514-Animals, pubmed-meshheading:10200514-Apoptosis, pubmed-meshheading:10200514-Arsenites, pubmed-meshheading:10200514-Caspase 3, pubmed-meshheading:10200514-Caspases, pubmed-meshheading:10200514-Cell Death, pubmed-meshheading:10200514-Cyclophosphamide, pubmed-meshheading:10200514-DNA Fragmentation, pubmed-meshheading:10200514-Embryonic Development, pubmed-meshheading:10200514-Enzyme Activation, pubmed-meshheading:10200514-Female, pubmed-meshheading:10200514-Head, pubmed-meshheading:10200514-Heart, pubmed-meshheading:10200514-Heating, pubmed-meshheading:10200514-Mice, pubmed-meshheading:10200514-Nucleosomes, pubmed-meshheading:10200514-Poly(ADP-ribose) Polymerases, pubmed-meshheading:10200514-Pregnancy, pubmed-meshheading:10200514-Sodium Compounds, pubmed-meshheading:10200514-Staining and Labeling, pubmed-meshheading:10200514-Teratogens
pubmed:year
1998
pubmed:articleTitle
Teratogen-induced cell death in postimplantation mouse embryos: differential tissue sensitivity and hallmarks of apoptosis.
pubmed:affiliation
Birth Defects Research Laboratory, Division of Congenital Defects, University of Washington, Seattle, WA 98195, USA. pemst@u.washington.edu
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.