|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
1999-4-29
|
|
pubmed:abstractText |
To determine the role of surfactant protein-A(SP-A) in antiviral host defense, mice lacking SP-A (SP-A-/-) were produced by targeted gene inactivation. SP-A-/- and control mice (SP-A+/+) were infected with respiratory syncytial virus (RSV) by intratracheal instillation. Pulmonary infiltration after infection was more severe in SP-A-/- than in SP-A+/+ mice and was associated with increased RSV plaque-forming units in lung homogenates. Pulmonary infiltration with polymorphonuclear leukocytes was greater in the SP-A-/- mice. Levels of proinflammatory cytokines tumor necrosis factor-alpha and interleukin-6 were enhanced in lungs of SP-A-/- mice. After RSV infection, superoxide and hydrogen peroxide generation was deficient in macrophages from SP-A-/- mice, demonstrating a critical role of SP-A in oxidant production associated with RSV infection. Coadministration of RSV with exogenous SP-A reduced viral titers and inflammatory cells in the lung of SP-A-/- mice. These findings demonstrate that SP-A plays an important host defense role against RSV in vivo.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-1314502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-1334078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-1634623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-1639094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-1651668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-1753101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-2171995,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-2185533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-2277737,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-2306370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-2388038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-2501785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-2573758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-2661270,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-2788203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-2797955,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-2820982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-2836491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-2909656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-3183639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-4355005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-6481852,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-7551395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-7810671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-7810675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-7844369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-7881683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-7977768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-8018334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-8418186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-8452675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-8476070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-8681574,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-8770070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-8790375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-8869194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-8891667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-9126996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-9130640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-9271309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-9311489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-9761768,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10194474-9922219
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0021-9738
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
103
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1015-21
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:10194474-Animals,
pubmed-meshheading:10194474-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:10194474-Cytokines,
pubmed-meshheading:10194474-Inflammation,
pubmed-meshheading:10194474-Lung,
pubmed-meshheading:10194474-Macrophages,
pubmed-meshheading:10194474-Mice,
pubmed-meshheading:10194474-Mice, Knockout,
pubmed-meshheading:10194474-Neutrophils,
pubmed-meshheading:10194474-Proteolipids,
pubmed-meshheading:10194474-Pulmonary Surfactant-Associated Protein A,
pubmed-meshheading:10194474-Pulmonary Surfactant-Associated Proteins,
pubmed-meshheading:10194474-Pulmonary Surfactants,
pubmed-meshheading:10194474-Reactive Oxygen Species,
pubmed-meshheading:10194474-Respiratory Syncytial Virus Infections,
pubmed-meshheading:10194474-Respiratory Syncytial Viruses,
pubmed-meshheading:10194474-Viral Plaque Assay
|
|
pubmed:year |
1999
|
|
pubmed:articleTitle |
Surfactant protein-A enhances respiratory syncytial virus clearance in vivo.
|
|
pubmed:affiliation |
Division of Pulmonary Biology, Children's Hospital Medical Center, Cincinnati, Ohio 45229-3039, USA. leviaO@chmcc.org
|
|
pubmed:publicationType |
Journal Article
|
