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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1999-4-20
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pubmed:abstractText |
Development of the system to express a suicide gene selectively in tumor cells is essential for gene therapy. We constructed a plasmid containing the diphtheria toxin A (DTA) fragment linked to human alpha-fetoprotein (AFP) promoter and enhancer, and tested whether it can exert its cytocidal effect selectively on AFP-producing cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-4790
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
145-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10102343-Carcinoma, Hepatocellular,
pubmed-meshheading:10102343-Chloramphenicol O-Acetyltransferase,
pubmed-meshheading:10102343-Diphtheria Toxin,
pubmed-meshheading:10102343-Enhancer Elements, Genetic,
pubmed-meshheading:10102343-Gene Therapy,
pubmed-meshheading:10102343-Humans,
pubmed-meshheading:10102343-Liver Neoplasms,
pubmed-meshheading:10102343-Peptide Fragments,
pubmed-meshheading:10102343-Promoter Regions, Genetic,
pubmed-meshheading:10102343-Transfection,
pubmed-meshheading:10102343-Tumor Cells, Cultured,
pubmed-meshheading:10102343-alpha-Fetoproteins
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pubmed:year |
1999
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pubmed:articleTitle |
Cell-specific expression of the diphtheria toxin A-chain coding sequence under the control of the upstream region of the human alpha-fetoprotein gene.
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pubmed:affiliation |
Department of Surgery, Keio University School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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