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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5408
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pubmed:dateCreated |
1999-4-1
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pubmed:databankReference |
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pubmed:abstractText |
Segregation Distorter (SD) in Drosophila melanogaster is a naturally occurring meiotic drive system in which the SD chromosome is transmitted from SD/SD+ males in vast excess over its homolog owing to the induced dysfunction of SD+-bearing spermatids. The Sd locus is the key distorting gene responsible for this phenotype. A genomic fragment from the Sd region conferred full distorting activity when introduced into the appropriate genetic background by germline transformation. The only functional product encoded by this fragment is a truncated version of the RanGAP nuclear transport protein. These results demonstrate that this mutant RanGAP is the functional Sd product.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
283
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1742-5
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:10073941-Animals,
pubmed-meshheading:10073941-Carrier Proteins,
pubmed-meshheading:10073941-Cell Nucleus,
pubmed-meshheading:10073941-Crosses, Genetic,
pubmed-meshheading:10073941-DNA, Complementary,
pubmed-meshheading:10073941-Drosophila Proteins,
pubmed-meshheading:10073941-Drosophila melanogaster,
pubmed-meshheading:10073941-Female,
pubmed-meshheading:10073941-GTPase-Activating Proteins,
pubmed-meshheading:10073941-Gene Duplication,
pubmed-meshheading:10073941-Gene Expression,
pubmed-meshheading:10073941-Genes, Insect,
pubmed-meshheading:10073941-Male,
pubmed-meshheading:10073941-Meiosis,
pubmed-meshheading:10073941-Nuclear Proteins,
pubmed-meshheading:10073941-RNA, Messenger,
pubmed-meshheading:10073941-Spermatids,
pubmed-meshheading:10073941-Sulfotransferases,
pubmed-meshheading:10073941-Transcription, Genetic,
pubmed-meshheading:10073941-Transformation, Genetic
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pubmed:year |
1999
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pubmed:articleTitle |
Truncated RanGAP encoded by the Segregation Distorter locus of Drosophila.
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pubmed:affiliation |
Laboratory of Genetics, 445 Henry Mall, University of Wisconsin, Madison, WI 53706, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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