Linked Life Data

10049161

Source:http://linkedlifedata.com/resource/pubmed/id/10049161

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-2-22
pubmed:abstractText
1. For a genetical approach to the molecular mechanisms of general anesthesia, we isolated 14 Drosophila transposon tagging mutants which showed altered sensitivities to diethylether anesthesia. Two mutated genes were identified and analyzed for their structures and functions. 2. One sensitive mutant, para(hd838), has a transposon, P-element, insertion in the 2nd intron of para locus (14C) which encodes an alpha subunit of a sodium channel. 3. Another sensitive mutant, eth(as)311. has a P-element in the 5'-untranslated region of Drosophila calreticulin gene (86BC). Calreticulin is known as a multifunctional calcium-binding protein in the endoplasmic reticulum of non-muscle cells. 4. We obtained their revertants to show that the P-element insertion in each gene induced the hypersensitivity to ether anesthesia. We describe here that the sodium channel and calreticulin might be targets for the ether anesthesia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0378-4274
pubmed:author
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
100-101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
329-37
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Molecular genetical analysis of Drosophila ether sensitive mutants.
pubmed:affiliation
Department of Life Sciences, Osaka Prefecture University, Sakai, Japan. gamo@el.cias.osakafu-u.ac.jp
pubmed:publicationType
Journal Article, Review