Linked Life Data

10025872

Source:http://linkedlifedata.com/resource/pubmed/id/10025872

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1999-3-4
pubmed:abstractText
Great interest has been focused on the chemoprevention of colonic carcinogenesis by oral administration of ursodeoxycholic acid (UDCA) because its administration reportedly reduces the incidence of colon cancer in animal experiments. To elucidate the precise role of UDCA in the chemoprevention of azoxymethane-induced colon carcinogenesis, we examined the expression levels of group II phospholipase A2 in the colonic tissue of UDCA-treated and untreated rats and correlated the levels with the findings of aberrant crypt foci, putative preneoplastic lesions. Twelve weeks after azoxymethane exposure, the total number of aberrant crypt foci in 0.4% UDCA-fed rats and 1% UDCA-fed rats was significantly decreased compared to the untreated animals. The mucosal concentrations of PGE2 and 6-keto PGF1alpha were significantly lower in the UDCA-treated rats than in untreated rats. In correlation with lowering, the enhanced activity, protein mass and mRNA levels of group II phospholipase A2 were significantly attenuated in the UDCA-treated animals. The chemopreventive role of UDCA in colon carcinogenesis may lie in its modulation of the arachidonate metabolism in colonic mucosa.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0304-3835
pubmed:author
pubmed:issnType
Print
pubmed:day
25
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
129-39
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:10025872-Animals, pubmed-meshheading:10025872-Anticarcinogenic Agents, pubmed-meshheading:10025872-Azoxymethane, pubmed-meshheading:10025872-Carcinogens, pubmed-meshheading:10025872-Colonic Neoplasms, pubmed-meshheading:10025872-DNA Primers, pubmed-meshheading:10025872-Gastrointestinal Agents, pubmed-meshheading:10025872-Gene Expression Regulation, Enzymologic, pubmed-meshheading:10025872-Gene Expression Regulation, Neoplastic, pubmed-meshheading:10025872-Immunoblotting, pubmed-meshheading:10025872-Male, pubmed-meshheading:10025872-Phospholipases A, pubmed-meshheading:10025872-Phospholipases A2, pubmed-meshheading:10025872-Precancerous Conditions, pubmed-meshheading:10025872-Prostaglandins, pubmed-meshheading:10025872-RNA, Messenger, pubmed-meshheading:10025872-Random Allocation, pubmed-meshheading:10025872-Rats, pubmed-meshheading:10025872-Rats, Inbred F344, pubmed-meshheading:10025872-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:10025872-Time Factors, pubmed-meshheading:10025872-Ursodeoxycholic Acid
pubmed:year
1998
pubmed:articleTitle
The chemopreventive role of ursodeoxycholic acid in azoxymethane-treated rats: suppressive effects on enhanced group II phospholipase A2 expression in colonic tissue.
pubmed:affiliation
Institute of Clinical Medicine, University of Tsukuba, Tsukuba City, Ibaraki, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't