Linked Life Data

CPATH-93809

Source:http://cbio.mskcc.org/cpath#CPATH-93809

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-93809http://www.biopax.org/relea...cGMP-inhibited 3',5'-cyclic phosphodiesterase Alld:imid
cpath:CPATH-93809http://www.biopax.org/relea...PDE3A_HUMANlld:imid
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cpath:CPATH-93809http://www.biopax.org/relea...Cyclic GMP-inhibited phosphodiesterase Alld:imid
cpath:CPATH-93809http://www.biopax.org/relea...CGI-PDE Alld:imid
cpath:CPATH-93809http://www.biopax.org/relea...FUNCTION: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (By similarity). CATALYTIC ACTIVITY: Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate. COFACTOR: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions (By similarity). ENZYME REGULATION: Inhibited by cGMP. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily. WEB RESOURCE: Name=Wikipedia; Note=PDE3 entry; URL="http://en.wikipedia.org/wiki/PDE3"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:imid
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