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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
cGMP-inhibited 3',5'-cyclic phosphodiesterase A
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| http://www.biopax.org/relea... |
PDE3A_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.1.4.17,
CGI-PDE A,
Cyclic GMP-inhibited phosphodiesterase A
|
| http://www.biopax.org/relea... |
FUNCTION: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes (By similarity). CATALYTIC ACTIVITY: Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate. COFACTOR: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions (By similarity). ENZYME REGULATION: Inhibited by cGMP. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily. WEB RESOURCE: Name=Wikipedia; Note=PDE3 entry; URL="http://en.wikipedia.org/wiki/PDE3"; COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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