Linked Life Data

CPATH-93726

Source:http://cbio.mskcc.org/cpath#CPATH-93726

Statements in which the resource exists.
SubjectPredicateObjectContext
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cpath:CPATH-93726http://www.biopax.org/relea...FUNCTION: Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Interacts with NPRL2. SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O15530-1; Sequence=Displayed; Name=2; IsoId=O15530-2; Sequence=VSP_004894; Name=3; IsoId=O15530-3; Sequence=VSP_004895; TISSUE SPECIFICITY: Appears to be expressed ubiquitously. PTM: Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation. SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 protein kinase domain. GENE SYNONYMS: PDK1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-93726http://www.biopax.org/relea...FUNCTION: Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Interacts with NPRL2. SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O15530-1; Sequence=Displayed; Name=2; IsoId=O15530-2; Sequence=VSP_004894; Name=3; IsoId=O15530-3; Sequence=VSP_004895; TISSUE SPECIFICITY: Appears to be expressed ubiquitously. PTM: Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation. SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 protein kinase domain. GENE SYNONYMS: PDK1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:imid
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