| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-385443,
cpath:CPATH-LOCAL-385443,
cpath:CPATH-LOCAL-385444,
cpath:CPATH-LOCAL-385444,
cpath:CPATH-LOCAL-385445,
cpath:CPATH-LOCAL-385445,
cpath:CPATH-LOCAL-385446,
cpath:CPATH-LOCAL-385446,
cpath:CPATH-LOCAL-385447,
cpath:CPATH-LOCAL-385447,
cpath:CPATH-LOCAL-385448,
cpath:CPATH-LOCAL-385448,
cpath:CPATH-LOCAL-392475,
cpath:CPATH-LOCAL-392475
|
| http://www.biopax.org/relea... |
3-phosphoinositide-dependent protein kinase 1,
3-phosphoinositide-dependent protein kinase 1
|
| http://www.biopax.org/relea... |
PDPK1_HUMAN,
PDPK1_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
2.7.11.1,
2.7.11.1,
hPDK1,
hPDK1
|
| http://www.biopax.org/relea... |
FUNCTION: Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Interacts with NPRL2. SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O15530-1; Sequence=Displayed; Name=2; IsoId=O15530-2; Sequence=VSP_004894; Name=3; IsoId=O15530-3; Sequence=VSP_004895; TISSUE SPECIFICITY: Appears to be expressed ubiquitously. PTM: Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation. SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 protein kinase domain. GENE SYNONYMS: PDK1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a general role in signaling processes and in development (By similarity). Isoform 3 is catalytically inactive. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. SUBUNIT: Interacts with NPRL2. SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O15530-1; Sequence=Displayed; Name=2; IsoId=O15530-2; Sequence=VSP_004894; Name=3; IsoId=O15530-3; Sequence=VSP_004895; TISSUE SPECIFICITY: Appears to be expressed ubiquitously. PTM: Phosphorylated on tyrosine and serine/threonine. Phosphorylation on Ser-241 in the activation loop is required for full activity. PDK1 itself can autophosphorylate Ser-241, leading to its own activation. SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily. SIMILARITY: Contains 1 PH domain. SIMILARITY: Contains 1 protein kinase domain. GENE SYNONYMS: PDK1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |