| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
SH2 domain-containing protein 3C
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| http://www.biopax.org/relea... |
SH2D3_HUMAN
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Novel SH2-containing protein 3
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| http://www.biopax.org/relea... |
FUNCTION: Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration (By similarity). SUBUNIT: Interacts with PTK2B. Isoform 2 interacts with BCAR1/CAS and NEDD9/HEF1 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=Associated with the membrane when EGF-stimulated. Found at ruffling membranes (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8N5H7-1; Sequence=Displayed; Name=2; IsoId=Q8N5H7-2; Sequence=VSP_017707; Name=3; IsoId=Q8N5H7-3; Sequence=VSP_017706; Note=No experimental confirmation available; Name=4; IsoId=Q8N5H7-4; Sequence=VSP_017708; Note=No experimental confirmation available; TISSUE SPECIFICITY: Ubiquitously expressed. SIMILARITY: Contains 1 Ras-GEF domain. SIMILARITY: Contains 1 SH2 domain. SEQUENCE CAUTION: Sequence=AAQ88456.1; Type=Erroneous initiation; GENE SYNONYMS: NSP3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch |