Linked Life Data

CPATH-87324

Source:http://cbio.mskcc.org/cpath#CPATH-87324

Statements in which the resource exists.
SubjectPredicateObjectContext
cpath:CPATH-87324rdf:typehttp://www.biopax.org/relea...lld:biogrid
cpath:CPATH-87324rdf:typehttp://www.biopax.org/relea...lld:cellmap
cpath:CPATH-87324http://www.biopax.org/relea...cpath:CPATH-LOCAL-358394lld:biogrid
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cpath:CPATH-87324http://www.biopax.org/relea...Axam2lld:biogrid
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cpath:CPATH-87324http://www.biopax.org/relea...FUNCTION: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). SUBUNIT: Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus. SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm. Note=Shuttles between cytoplasm and nucleus. DOMAIN: The N-terminus is necessary and sufficient for nuclear envelope targeting. PTM: Polyubiquitinated; which leads to proteasomal degradation. SIMILARITY: Belongs to the peptidase C48 family. GENE SYNONYMS: KIAA1331. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-87324http://www.biopax.org/relea...FUNCTION: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). SUBUNIT: Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus. SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm. Note=Shuttles between cytoplasm and nucleus. DOMAIN: The N-terminus is necessary and sufficient for nuclear envelope targeting. PTM: Polyubiquitinated; which leads to proteasomal degradation. SIMILARITY: Belongs to the peptidase C48 family. GENE SYNONYMS: KIAA1331. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:cellmap
cpath:CPATH-87324skos:exactMatchuniprot-protein:Q9HC62lld:mappings
cpath:CPATH-87324skos:closeMatchentrez-gene:59343lld:mappings
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cpath:CPATH-LOCAL-11373880http://www.biopax.org/relea...cpath:CPATH-87324lld:biogrid
cpath:CPATH-LOCAL-11404900http://www.biopax.org/relea...cpath:CPATH-87324lld:biogrid
cpath:CPATH-LOCAL-11518794http://www.biopax.org/relea...cpath:CPATH-87324lld:biogrid
cpath:CPATH-LOCAL-11690169http://www.biopax.org/relea...cpath:CPATH-87324lld:biogrid
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