| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... |
cpath:CPATH-LOCAL-358394,
cpath:CPATH-LOCAL-358394,
cpath:CPATH-LOCAL-358395,
cpath:CPATH-LOCAL-358395,
cpath:CPATH-LOCAL-358396,
cpath:CPATH-LOCAL-358396,
cpath:CPATH-LOCAL-358397,
cpath:CPATH-LOCAL-358397,
cpath:CPATH-LOCAL-358398,
cpath:CPATH-LOCAL-358398,
cpath:CPATH-LOCAL-358399,
cpath:CPATH-LOCAL-358399,
cpath:CPATH-LOCAL-358400,
cpath:CPATH-LOCAL-358400,
cpath:CPATH-LOCAL-368035,
cpath:CPATH-LOCAL-368035
|
| http://www.biopax.org/relea... |
Sentrin-specific protease 2,
Sentrin-specific protease 2
|
| http://www.biopax.org/relea... |
SENP2_HUMAN,
SENP2_HUMAN
|
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
3.4.22.-,
3.4.22.-,
Axam2,
Axam2,
SMT3-specific isopeptidase 2,
SMT3-specific isopeptidase 2,
Sentrin/SUMO-specific protease SENP2,
Sentrin/SUMO-specific protease SENP2,
Smt3ip2,
Smt3ip2
|
| http://www.biopax.org/relea... |
FUNCTION: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). SUBUNIT: Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus. SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm. Note=Shuttles between cytoplasm and nucleus. DOMAIN: The N-terminus is necessary and sufficient for nuclear envelope targeting. PTM: Polyubiquitinated; which leads to proteasomal degradation. SIMILARITY: Belongs to the peptidase C48 family. GENE SYNONYMS: KIAA1331. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.,
FUNCTION: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). SUBUNIT: Binds to SUMO2 and SUMO3 (By similarity). Interacts with the C-terminal domain of NUP153 via its N-terminus. SUBCELLULAR LOCATION: Nucleus, nuclear pore complex. Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side. Cytoplasm. Note=Shuttles between cytoplasm and nucleus. DOMAIN: The N-terminus is necessary and sufficient for nuclear envelope targeting. PTM: Polyubiquitinated; which leads to proteasomal degradation. SIMILARITY: Belongs to the peptidase C48 family. GENE SYNONYMS: KIAA1331. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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| skos:exactMatch | |
| skos:closeMatch |