| Predicate | Object |
|---|---|
| rdf:type | |
| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
Thrombospondin-2
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| http://www.biopax.org/relea... |
TSP2_MOUSE
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| http://www.biopax.org/relea... | |
| http://www.biopax.org/relea... |
FUNCTION: Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Ligand for CD36 mediating antiangiogenic properties. SUBUNIT: Homotrimer; disulfide-linked. Can bind to fibrinogen, fibronectin, laminin and type V collagen (By similarity). Interacts (via the TSP type I repeats) with CD36; the interaction conveys an antiangiogenic effect. Interacts (via the TSP type I repeats) with HRG; the interaction blocks the antiangiogenic effect of THBS2 with CD36. Can bind to fibrinogen, fibronectin, laminin. SIMILARITY: Belongs to the thrombospondin family. SIMILARITY: Contains 3 EGF-like domains. SIMILARITY: Contains 1 TSP C-terminal (TSPC) domain. SIMILARITY: Contains 1 TSP N-terminal (TSPN) domain. SIMILARITY: Contains 3 TSP type-1 domains. SIMILARITY: Contains 8 TSP type-3 repeats. SIMILARITY: Contains 1 VWFC domain. GENE SYNONYMS: Tsp2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.
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