Linked Life Data

CPATH-63882

Source:http://cbio.mskcc.org/cpath#CPATH-63882

Statements in which the resource exists.
SubjectPredicateObjectContext
cpath:CPATH-63882rdf:typehttp://www.biopax.org/relea...lld:biogrid
cpath:CPATH-63882rdf:typehttp://www.biopax.org/relea...lld:cellmap
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262561lld:biogrid
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262561lld:cellmap
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262562lld:biogrid
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262562lld:cellmap
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262563lld:biogrid
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262563lld:cellmap
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262564lld:biogrid
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262564lld:cellmap
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262565lld:biogrid
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262565lld:cellmap
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262566lld:biogrid
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262566lld:cellmap
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262567lld:biogrid
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262567lld:cellmap
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262568lld:biogrid
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262568lld:cellmap
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-270222lld:biogrid
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-270222lld:cellmap
cpath:CPATH-63882http://www.biopax.org/relea...Sprouty-related, EVH1 domain-containing protein 2lld:biogrid
cpath:CPATH-63882http://www.biopax.org/relea...Sprouty-related, EVH1 domain-containing protein 2lld:cellmap
cpath:CPATH-63882http://www.biopax.org/relea...SPRE2_HUMANlld:biogrid
cpath:CPATH-63882http://www.biopax.org/relea...SPRE2_HUMANlld:cellmap
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262569lld:biogrid
cpath:CPATH-63882http://www.biopax.org/relea...cpath:CPATH-LOCAL-262569lld:cellmap
cpath:CPATH-63882http://www.biopax.org/relea...Spred-2lld:biogrid
cpath:CPATH-63882http://www.biopax.org/relea...Spred-2lld:cellmap
cpath:CPATH-63882http://www.biopax.org/relea...FUNCTION: Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. SUBUNIT: Interacts with Ras (By similarity). Homodimer and heterodimer. Able to interact with SPRED1 to form heterodimers. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cytoplasm. Note=Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules. TISSUE SPECIFICITY: Expressed in liver, skin, small intestine, salivary gland and prostate. PTM: Phosphorylated on tyrosine. Phosphorylation of Tyr-228 and Tyr-231 are required for ubiquitination. PTM: Ubiquitinated; leading to degradation by the proteasome. SIMILARITY: Contains 1 KBD domain. SIMILARITY: Contains 1 SPR (sprouty) domain. SIMILARITY: Contains 1 WH1 domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:biogrid
cpath:CPATH-63882http://www.biopax.org/relea...FUNCTION: Tyrosine kinase substrate that inhibits growth-factor- mediated activation of MAP kinase. SUBUNIT: Interacts with Ras (By similarity). Homodimer and heterodimer. Able to interact with SPRED1 to form heterodimers. SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cytoplasmic vesicle, secretory vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Cytoplasm. Note=Especially found in the cytoplasm of the stratum spinosum cells called membrane-coated granules. TISSUE SPECIFICITY: Expressed in liver, skin, small intestine, salivary gland and prostate. PTM: Phosphorylated on tyrosine. Phosphorylation of Tyr-228 and Tyr-231 are required for ubiquitination. PTM: Ubiquitinated; leading to degradation by the proteasome. SIMILARITY: Contains 1 KBD domain. SIMILARITY: Contains 1 SPR (sprouty) domain. SIMILARITY: Contains 1 WH1 domain. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License.lld:cellmap
cpath:CPATH-63882skos:exactMatchuniprot-protein:Q7Z698lld:mappings
cpath:CPATH-63882skos:closeMatchentrez-gene:200734lld:mappings
cpath:CPATH-LOCAL-11052775http://www.biopax.org/relea...cpath:CPATH-63882lld:biogrid
cpath:CPATH-LOCAL-11103039http://www.biopax.org/relea...cpath:CPATH-63882lld:biogrid
cpath:CPATH-LOCAL-7754075http://www.biopax.org/relea...cpath:CPATH-63882lld:cellmap
cpath:CPATH-LOCAL-7754373http://www.biopax.org/relea...cpath:CPATH-63882lld:cellmap
cpath:CPATH-LOCAL-7754385http://www.biopax.org/relea...cpath:CPATH-63882lld:cellmap